Angiogenesis and ovarian cancer
Angiogenesis and ovarian cancer
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DOI：
10.1007/s12094-009-0406-y
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发表时间：
2009-09-01
影响因子：
3.4
通讯作者：
Redondo, Andres
中科院分区：
文献类型：
--
作者：
Gomez-Raposo, Cesar;Mendiola, Marta;Redondo, Andres
在西方社会，卵巢癌是妇科癌症相关死亡率的最重要原因。诊断时的年龄、疾病程度（如FIGO状态所表示）、初次手术的成功率和肿瘤的组织病理学特征是重要的预后标志物。大多数卵巢癌患者表现为晚期疾病（FIGO III/IV期），这组患者的中位生存期仅为3年。因此，需要新的治疗方法来改善这种疾病的结果。血管生成，即新生血管血液供应的发展，是恶性肿瘤生长和转移的传播中的关键步骤，并且代表了有希望的靶点。本文就血管生成、VEGF生物学特性及血管生成因子在卵巢癌预后中的潜在价值作一综述。
Ovarian carcinoma is the most important cause of gynaecological cancer-related mortality in Western societies. The age at diagnosis, extent of disease (as expressed by FIGO state), success of primary surgery and the histopathological features of the tumour are important prognostic markers. The majority of patients with ovarian cancer present with advanced disease (FIGO stage III/IV) and in this group of patients the median survival is only three years. New treatment approaches are therefore required to improve outcome in this disease. Angiogenesis, the development of a neovascular blood supply, is a critical step in the propagation of malignant tumour growth and metastasis and represents a promising target. This review will focus on angiogenesis, VEGF biology and the potential value of angiogenic factors with prognostic value in ovarian cancer.