NEURO-BEHAVIORAL CHANGES ASSOCIATED WITH CAUDATE LESIONS
NEURO-BEHAVIORAL CHANGES ASSOCIATED WITH CAUDATE LESIONS
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DOI：
10.1212/wnl.39.3.349
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发表时间：
1989-03-01
期刊：
影响因子：
9.9
通讯作者：
LEWANDOWSKI, KS
中科院分区：
文献类型：
--
作者：
MENDEZ, MF;ADAMS, NL;LEWANDOWSKI, KS
我们报告了12例尾状核病变患者的行为和认知特征，其中11例单侧，1例双侧。这些患者出现急性行为改变，表现为冷漠、抑制解除或严重的情感障碍。人格改变的模式与尾状核内病变的大小和位置相关，但与偏侧性无关。7例患者与对照组进行了一系列神经心理学测试。他们在需要计划和排序的任务上的表现受损。他们的注意力持续时间短，情节和语义项目的自由回忆减少，识别记忆分数良好。类似的行为和认知变化也发生在早期亨廷顿病、额叶损伤患者和尾状核损伤动物中，并且对应于特定的额叶-尾状核回路的紊乱。这些结果暗示尾状核介导前额叶行为，并可能在记忆的概念整合。
We report behavioral and cognitive characteristics of 12 patients with caudate nuclei lesions, 11 unilateral and one bilateral. These patients developed an acute behavioral change characterized by apathy, disinhibition, or a major affective disturbance. The pattern of personality change correlated with size and location of lesion within the caudate but not the laterality. Seven patients were further compared with matched controls on a series of neuropsychological tests. Their performance was impaired on tasks requiring planning and sequencing. They had short attention spans and decreased free recall of episodic and semantic items with good recognition memory scores. Similar behavioral and cognitive changes also occur in early Huntington''s disesase, frontal-lesioned patients, and caudate-lesioned animals, and correspond to disturbances of specific frontal-caudate circuits. These results implicate the caudate nuclei in mediating prefrontal behaviors and possibly in the conceptual integration of memories.