Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: a case-control study.
Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: a case-control study.
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DOI：
10.1186/1476-069x-12-20
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发表时间：
2013-02-22
期刊：
影响因子：
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通讯作者：
Ward MH
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文献类型：
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作者：
Pronk A;Nuckols JR;De Roos AJ;Airola M;Colt JS;Cerhan JR;Morton L;Cozen W;Severson R;Blair A;Cleverly D;Ward MH
在欧洲的研究中，居住在城市固体废物焚化炉附近是二恶英排放的主要历史来源，与非霍奇金淋巴瘤（NHL）的风险增加有关。我们的研究的目的是评估住宅附近的工业燃烧设施和二恶英排放量的估计在美国NHL的风险。我们在四个国家癌症研究所监测流行病学和最终结果中心（底特律，爱荷华州，洛杉矶，西雅图）进行了一项基于人群的NHL病例对照研究（1998-2000）。诊断前15年的居住史（对照组的日期相似）与环境保护局二恶英排放设施数据库中的969例和749例对照组相关联。我们评估了10种设施类型（占美国排放量的85%以上）的接近程度（3公里和5公里）以及距离加权平均排放指数（AEI [ng毒性当量商数（TEQ）/年]）。邻近任何二恶英排放设施与NHL风险无关（3 km OR = 1.0，95%CI 0.8-1.3）。居住在水泥窑附近的风险升高（5公里OR = 1.7，95% CI 0.8-3.3; 3公里OR = 3.8，95% CI 1.1-14.0），居住在城市固体废物焚化炉附近的风险降低（5公里OR = 0.5，95% CI 0.3-0.9; 3公里OR = 0.3，95% CI 0.1-1.4）。AEI与总体NHL风险无关。最高四分位数与最低四分位数相比，边缘区淋巴瘤的风险增加（5 km OR = 2.6，95% CI 1.0-6.8; 3 km OR = 3.0，95% CI 1.1-8.3）。总体而言，我们没有发现与住宅暴露于二恶英和NHL风险。然而，高排放和边缘区淋巴瘤和特定设施类型和所有NHL的研究结果提供了一些证据的关联，值得进一步研究。
Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. We conducted a population-based case–control study of NHL (1998–2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR = 1.0, 95% CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR = 1.7, 95% CI 0.8-3.3; 3 km OR = 3.8, 95% CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR = 0.5, 95% CI 0.3-0.9; 3 km OR = 0.3, 95% CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR = 2.6, 95% CI 1.0-6.8; 3 km OR = 3.0, 95% CI 1.1-8.3). Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.