Involving Vulnerable Populations of Youth in HIV Prevention Clinical Research
Involving Vulnerable Populations of Youth in HIV Prevention Clinical Research
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DOI：
10.1097/qai.0b013e3181e3627d
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Caceres, Carlos F.
中科院分区：
文献类型：
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作者：
Borek, Nicolette;Allison, Susannah;Caceres, Carlos F.
青少年仍然是感染艾滋病毒的高风险人群，其中男男性行为者以及吸毒和/或有心理健康问题的青少年感染艾滋病毒的风险尤其高。多种因素可能相互作用，给这些青少年带来风险。让弱势青少年参与艾滋病毒预防研究可能会在入学、保留和试验依从性方面带来独特的挑战。与弱势青少年成功接触的例子为将这些青少年纳入临床试验的可行性提供了令人鼓舞的证据。在对弱势青少年进行生物医学艾滋病毒预防研究之前，必须考虑伦理挑战，特别是在全球背景下。鉴于导致其高风险状态的许多个人和背景因素，将弱势青年群体纳入艾滋病毒预防临床研究至关重要。
Adolescents continue to be at high risk for HIV infection, with young men who have sex with men and youth with drug abuse and/or mental health problems at particularly high risk. Multiple factors may interact to confer risk for these youth. Engaging vulnerable youth in HIV prevention research can present unique challenges in the areas of enrollment, retention, and trial adherence. Examples of successful engagement with vulnerable youth offer encouraging evidence for the feasibility of including these youth in clinical trials. Ethical challenges must be taken into consideration before embarking on biomedical HIV prevention studies with vulnerable youth, especially in the global context. Given the many individual and contextual factors that contribute to their high-risk status, it is essential that vulnerable youth populations be included in HIV prevention clinical research studies.