The role of cholesterol in invasion and growth of malaria parasites.
The role of cholesterol in invasion and growth of malaria parasites.
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DOI：
10.3389/fcimb.2022.984049
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
疟疾寄生虫是单细胞真核病原体，其通过涉及两种宿主（按蚊和脊椎动物宿主）的复杂生命周期发展。在整个生命周期中，寄生虫会遇到各种不同的条件，并以不同的方式生存，从脊椎动物宿主的细胞内生活方式到蚊子的细胞外阶段。虽然寄生虫依赖胆固醇生长，但寄生虫与胆固醇的关系不明确：寄生虫入侵宿主细胞（包括肝细胞和红细胞）以及寄生虫在这些细胞中的发育都需要胆固醇。然而，寄生虫本身无法产生胆固醇，并且似乎会主动从其自身的质膜中去除胆固醇，从而在感染的宿主红细胞内建立胆固醇梯度。总的来说，寄生虫依赖于宿主胆固醇并仔细控制其运输。在这里，我们描述了胆固醇在寄生虫不同生命周期阶段的作用。
Malaria parasites are unicellular eukaryotic pathogens that develop through a complex lifecycle involving two hosts, an anopheline mosquito and a vertebrate host. Throughout this lifecycle, the parasite encounters widely differing conditions and survives in distinct ways, from an intracellular lifestyle in the vertebrate host to exclusively extracellular stages in the mosquito. Although the parasite relies on cholesterol for its growth, the parasite has an ambiguous relationship with cholesterol: cholesterol is required for invasion of host cells by the parasite, including hepatocytes and erythrocytes, and for the development of the parasites in those cells. However, the parasite is unable to produce cholesterol itself and appears to remove cholesterol actively from its own plasma membrane, thereby setting up a cholesterol gradient inside the infected host erythrocyte. Overall a picture emerges in which the parasite relies on host cholesterol and carefully controls its transport. Here, we describe the role of cholesterol at the different lifecycle stages of the parasites.
影响因子：
4.4
作者：
Frech C;Chen N
通讯作者：
Chen N
影响因子：
4.3
作者：
Frech C;Chen N
通讯作者：
Chen N