CYTOARCHITECTURE OF SEROTONIN-SYNTHESIZING NEURONS IN THE PONTINE TEGMENTUM OF THE HUMAN BRAIN
CYTOARCHITECTURE OF SEROTONIN-SYNTHESIZING NEURONS IN THE PONTINE TEGMENTUM OF THE HUMAN BRAIN
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DOI：
10.1002/syn.890070407
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发表时间：
1991-04-01
期刊：
影响因子：
2.3
通讯作者：
TORK, I
中科院分区：
文献类型：
--
作者：
BAKER, KG;HALLIDAY, GM;TORK, I
我们采用免疫组织化学和形态测定方法来研究成年人脑桥网状结构中的血清素合成（PH8 免疫反应性）神经元。在三个细胞结构区域发现了 PH8 免疫反应性神经元：中缝核 (MnR)、口腔桥脑网状核 (PnO) 和脑膜上区域（B9 组）。根据细胞大小、形态和位置，可以区分 MnR（背侧、中线和旁正中细胞簇）和 PnO（背侧和中央细胞簇）内的不同亚群，而 B9 内没有明显的细胞簇。我们估计，人类脑桥被盖内大约有 125,000 个 PH8 免疫反应性神经元； MnR 中有 64,400 个，PnO 中有 30,700 个，B9 中有 29,000 个。人类脑桥被盖中有大量合成血清素的神经元，而在大鼠和猫等非灵长类动物中，合成血清素的神经元相对较少。非人类灵长类动物也有大量的脑桥血清素能神经元，但这些神经元的形态及其空间排列与人类显着不同。这些结果是关于这些神经元在人类中可能的投射和功能进行讨论的。
We have employed immunohistochemical and morphometric procedures to study serotonin-synthesizing (PH8-immunoreactive) neurons in the pontine reticular formation of the adult human. PH8-immunoreactive neurons were found in three cytoarchitectural regions: the median raphe nucleus (MnR), oral pontine reticular nucleus (PnO), and supralemniscal region (group B9). On the basis of cell size, morphology, and position, it was possible to distinguish distinct subgroups within the MnR (dorsal, midline, and paramedian cell clusters) and within the PnO (dorsal and central cell clusters), whereas within the B9 there were no distinct cell clusters. We have estimated that there are approximately 125,000 PH8-immunoreactive neurons in the human pontine tegmentum; 64,400 in the MnR, 30,700 in PnO and 29,000 in B9. The large numbers of serotonin-synthesizing neurons in the human pontine tegmentum contrasts with their relative paucity in nonprimate species such as rats and cats. Nonhuman primates also have large numbers of pontine serotonergic neurons but the morphology of these neurons and their spatial arrangement is significantly different in humans. These results are discussed with respect to the possible projections and functions of these neurons in humans.