A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation.
A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation.
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DOI：
10.1109/tnsre.2012.2189163
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Deadwyler SA
中科院分区：
文献类型：
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作者：
Hampson RE;Song D;Chan RH;Sweatt AJ;Riley MR;Gerhardt GA;Shin DC;Marmarelis VZ;Berger TW;Deadwyler SA
协作研究已经表征了多神经元海马群如何编码啮齿动物在延迟不匹配到样本(DNMS)任务中随后成功执行所需的记忆，并利用这些信息为记忆假体提供提高性能的基础。通过采用一个独特的非线性动态多输入/多输出(MIMO)模型，该模型发展并适应于从同时记录的CA1和CA3活动中获得的海马神经系综放电模式，有可能提取在样本阶段编码的信息，这是在任务的非匹配阶段成功完成任务所必需的。将这一MIMO模型扩展到在线传递电刺激，传递到模仿成功的CA1放电模式的相同记录位点，提供了在逐个试验的基础上提高性能水平的手段。几个控制程序的包含为有效的MIMO模型产生的电刺激模式的特异性提供了证据。在刺激和非刺激试验中，在多次重复MIMO刺激的情况下，DNMS任务绩效的累积增加表明，MIMO模型作为假体设备的实用性增加，这表明随着持续暴露，整体系统发生了改变。这里报告的结果与先前的演示兼容并扩展，进一步支持MIMO模型作为一种有效的皮质假体的候选。
Collaborative investigations have characterized how multineuron hippocampal ensembles encode memory necessary for subsequent successful performance by rodents in a delayed nonmatch to sample (DNMS) task and utilized that information to provide the basis for a memory prosthesis to enhance performance. By employing a unique nonlinear dynamic multi-input/multi-output (MIMO) model, developed and adapted to hippocampal neural ensemble firing patterns derived from simultaneous recorded CA1 and CA3 activity, it was possible to extract information encoded in the sample phase necessary for successful performance in the nonmatch phase of the task. The extension of this MIMO model to online delivery of electrical stimulation delivered to the same recording loci that mimicked successful CA1 firing patterns, provided the means to increase levels of performance on a trial-by-trial basis. Inclusion of several control procedures provides evidence for the specificity of effective MIMO model generated patterns of electrical stimulation. Increased utility of the MIMO model as a prosthesis device was exhibited by the demonstration of cumulative increases in DNMS task performance with repeated MIMO stimulation over many sessions on both stimulation and nonstimulation trials, suggesting overall system modification with continued exposure. Results reported here are compatible with and extend prior demonstrations and further support the candidacy of the MIMO model as an effective cortical prosthesis.