Genome imprinting phenomena on mouse chromosome 7.
Genome imprinting phenomena on mouse chromosome 7.
复制标题
小鼠7号染色体上的基因组印记现象。
DOI：
10.1017/s0016672300035333
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
C. Beechey
中科院分区：
文献类型：
--
作者：
Antony G. Searle;C. Beechey
为研究小鼠7号染色体上的遗传互补，将T（7;15）9 H相互易位的杂合子与白化病（c）和under white（uw）作为遗传标记进行杂交。已知15号染色体显示正常互补。其中一个亲本为c/c和另一个野生型的正反杂交在出生时均未产生白化病后代，尽管预期约为17%，但当母亲为c/c且父亲为野生型时，回收了白化病胎儿。这些产品的母亲重复/父亲的缺陷远端7显着滞后与小胎盘。当父亲为c/c且母亲为野生型时，未发现白化病胎仔，这表明早期致死。以uw（15号染色体）为近端标记的等代杂交，当母体为uw/uw时，产生正常的under white后代，但在正反交中，推定的under whites出现小胎座、发育迟缓和新生儿死亡。这些异常新生儿可能在近端7有母亲重复/父亲缺陷。这些和其他研究结果表明，一个区域的缺陷互补可能位于T（7;18）50 H的断点在7 E2-F2的远端，而另一个是在着丝粒和7 B3之间。人-小鼠同源性的检查表明，三种病理性人类疾病（Beckwith-Weidemann综合征，营养不良性肌强直和横纹肌肉瘤）的基因座与差异亲代传递可能位于小鼠7号染色体上受印迹现象影响的同源区域。
Heterozygotes for the reciprocal translocation T(7;15)9H were intercrossed, with albino (c) and underwhite (uw) as genetic markers, in order to study genetic complementation in mouse chromosome 7. Chromosome 15 is known to show normal complementation. Neither reciprocal cross in which one parent was c/c and the other wild type yielded albino progeny at birth although about 17% would be expected, but albino foetuses were recovered when the mother was c/c and father wild type. These products of maternal duplication/paternal deficiency for distal 7 were markedly retarded with small placentae. No albino foetuses were found when the father was c/c and mother wild type, which suggested earlier lethality. Equivalent crosses with uw (chromosome 15) as proximal marker gave normal underwhite progeny when the mother was uw/uw but small placentae, retardation and neonatal death of presumptive underwhites in the reciprocal cross. These abnormal newborn would have had a maternal duplication/paternal deficiency for proximal 7. These and other findings indicate that one region of defective complementation probably lies distal to the breakpoint of T(7;18)50H at 7E2-F2, while another is between the centromere and 7B3. Examination of man-mouse homologies suggests that the loci for three pathological human conditions (Beckwith-Weidemann syndrome, dystrophia myotonia and rhabdomyosarcoma) with differential parental transmission may be located in homologous regions to those affected by imprinting phenomena on mouse chromosome 7.
影响因子：
11.1
作者：
D. Solter
通讯作者：
D. Solter
基因组印记：小鼠 16 号染色体的正常互补。
DOI：
10.1017/s001667230002869x
发表时间：
1989
期刊：
Genetical research
影响因子：
--
作者：
Berger,CN;Epstein,CJ
通讯作者：
Epstein,CJ
肾母细胞瘤中母体 11 号染色体等位基因的非随机丢失。
影响因子：
9.8
作者：
Schroeder,WT;Chao,LY;Dao,DD;Strong,LC;Pathak,S;Riccardi,V;Lewis,WH;Saunders,GF
通讯作者：
Saunders,GF