Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence
Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence
复制标题
DOI：
10.1080/14622200801978672
复制
发表时间：
2008-04-01
影响因子：
4.7
通讯作者：
Madden, Pamela A. F.
中科院分区：
文献类型：
--
作者：
Agrawal, Arpana;Knopik, Valerie S.;Madden, Pamela A. F.
怀孕期间吸烟（CSDP）与后代的许多负面结果有关。因此，阐明复方丹参滴丸的相关性以及复方丹参滴丸与尼古丁依赖的相关程度是降低普通人群尼古丁依赖率的重要一步。使用来自 1,134 名澳大利亚成年女性同卵和异卵双胞胎的数据，我们探讨了 CSDP 与社会人口统计学和精神病学相关性以及 CSDP 与吸烟模式之间的关联。此外，我们还研究了遗传和环境影响对复方丹参滴丸的作用，并调查了这些潜在风险因素是否与尼古丁依赖倾向相同。与社区母亲样本和仅在怀孕期间吸烟的女性相比，在整个怀孕期间吸烟的女性报告了更严重的依赖性和更多不成功的戒烟尝试。教育程度、每周去教堂、配偶当前吸烟和尼古丁依赖也与 CSDP 相关。遗传影响解释了 CSDP 变异的 34%，其余与非共享环境因素有关。对 CSDP 的遗传影响很大一部分与 DSM-III-R 尼古丁依赖性相同，非共同的环境影响几乎没有重叠。治疗提供者在向准妈妈提供有关 CSDP 潜在风险的咨询时，需要考虑终生戒烟困难史，以及社会背景和精神合并症，尤其是在怀孕期间。
Cigarette smoking during pregnancy (CSDP) is associated with a number of negative outcomes in the offspring. Therefore, clarifying the correlates of CSDP and the extent to which CSDP is associated with nicotine dependence is an important step toward reducing its rate in the general population. Using data from 1,134 adult Australian female monozygotic and dizygotic twin pairs, we explored the associations between CSDP and sociodemographic and psychiatric correlates and between CSDP and patterns of cigarette smoking. Further, we examined the role of heritable and environmental influences on CSDP and investigated whether these latent risk factors are shared with a predisposition to nicotine dependence. Women smoking during an entire pregnancy reported heavier dependence and more unsuccessful quit attempts, compared with the community sample of mothers and with women who smoked during only part of a pregnancy. Educational attainment, weekly church attendance, spousal current smoking, and nicotine dependence also were associated with CSDP. Heritable influences explained 34% of the variation in CSDP, with the remainder related to nonshared environmental factors. A large proportion of the genetic influences on CSDP were shared with DSM-III-R nicotine dependence, with little overlap across the nonshared environmental influences. A lifetime history of difficulty with smoking cessation, in conjunction with, social background and psychiatric comorbidity, especially during pregnancy, needs to be considered by treatment providers when counseling expectant mothers about the potential risks of CSDP.