The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.
The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.
复制标题
血色病（HFE）基因型对铅冶炼工人铅负荷和铁代谢的影响
DOI：
10.1371/journal.pone.0101537
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhou F
中科院分区：
文献类型：
--
作者：
Fan G;Du G;Li H;Lin F;Sun Z;Yang W;Feng C;Zhu G;Li Y;Chen Y;Jiao H;Zhou F
背景过量的有毒铅（Pb）和铁代谢紊乱与许多疾病和公共卫生问题有关。铁代谢基因，如血色素沉着症（HFE）基因，已被报道为铅吸收和储存的修饰剂。然而，在职业性高铅暴露的亚洲人群中缺乏HFE基因的研究。目的探讨HFE基因型（野生型、H63 D变异型和C282 Y变异型）对亚洲高职业铅暴露工人铅负荷和铁代谢的影响。方法对某铅冶炼厂771名职工进行铅中毒指标、铁代谢指标检测及HFE基因型鉴定。进行描述性和多变量分析。结果在771例受检者中检出45例H63 D变异携带者，未检出C282 Y变异携带者。与野生型基因型受试者相比，H63 D变异携带者的血铅水平更高，即使在控制了年龄、性别、婚姻、教育、吸烟和铅暴露水平等因素后。多变量分析还表明，H63 D基因型修改血铅水平和身体铁负荷/转铁蛋白之间的关联。结论在该亚洲人群中未发现C282 Y变异。H63 D基因型改变了铅和铁代谢之间的关联，使得血铅增加与H63 D变体中较高的体铁含量或较低的转铁蛋白相关。这表明，H63 D变异携带者可能是一个潜在的高度脆弱的亚群，如果他们暴露于高水平的职业铅。
Background Both an excess of toxic lead (Pb) and an essential iron disorder have been implicated in many diseases and public health problems. Iron metabolism genes, such as the hemochromatosis (HFE) gene, have been reported to be modifiers for lead absorption and storage. However, the HFE gene studies among the Asian population with occupationally high lead exposure are lacking. Objectives To explore the modifying effects of the HFE genotype (wild-type, H63D variant and C282Y variant) on the Pb load and iron metabolism among Asian Pb-workers with high occupational exposure. Methods Seven hundred and seventy-one employees from a lead smelter manufacturing company were tested to determine their Pb intoxication parameters, iron metabolic indexes and identify the HFE genotype. Descriptive and multivariate analyses were conducted. Results Forty-five H63D variant carriers and no C282Y variant carrier were found among the 771 subjects. Compared with subjects with the wild-type genotype, H63D variant carriers had higher blood lead levels, even after controlling for factors such as age, sex, marriage, education, smoking and lead exposure levels. Multivariate analyses also showed that the H63D genotype modifies the associations between the blood lead levels and the body iron burden/transferrin. Conclusions No C282Y variant was found in this Asian population. The H63D genotype modified the association between the lead and iron metabolism such that increased blood lead is associated with a higher body iron content or a lower transferrin in the H63D variant. It is indicated that H63D variant carriers may be a potentially highly vulnerable sub-population if they are exposed to high lead levels occupationally.
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影响因子：
6.7
作者：
Geier, A;Reugels, M;Lammert, F
通讯作者：
Lammert, F
影响因子：
3.9
作者：
Barnum-Huckins, K;Adrian, GS
通讯作者：
Adrian, GS
铁代谢基因的变异预示着幼儿的血铅水平较高。
影响因子：
10.4
作者：
Hopkins MR;Ettinger AS;Hernández-Avila M;Schwartz J;Téllez-Rojo MM;Lamadrid-Figueroa H;Bellinger D;Hu H;Wright RO
通讯作者：
Wright RO
影响因子：
24.5
作者：
Dupic, F;Fruchon, S;Coppin, H
通讯作者：
Coppin, H
影响因子：
8.8
作者：
Burke, W;Imperatore, G;Khoury, MJ
通讯作者：
Khoury, MJ