The role of osteocalcin in human glucose metabolism: marker or mediator?
The role of osteocalcin in human glucose metabolism: marker or mediator?
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DOI：
10.1038/nrendo.2012.201
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发表时间：
2013-01
影响因子：
40.5
通讯作者：
Gundberg, Caren
中科院分区：
文献类型：
--
作者：
Booth, Sarah L.;Centi, Amanda;Smith, Steven R.;Gundberg, Caren
越来越多的证据支持骨骼和能量代谢之间的联系。这些相互作用由多种激素、细胞因子和营养素介导。在这里，回顾了骨钙素在调节人类葡萄糖代谢中作用的证据。骨钙素是一种骨基质蛋白，通过其维生素K依赖性γ-羧化形式调节羟基磷灰石的大小和形状。在循环中，骨钙素的浓度是骨形成的量度。据报道，骨钙素的羧基化不足形式在小鼠的葡萄糖代谢中具有活性。人体血清总骨钙素浓度与葡萄糖代谢指标呈负相关;然而，关于未羧化骨钙素在葡萄糖代谢中的作用，人体数据尚无定论，因为大多数研究未考虑维生素K对未羧化骨钙素比例的影响，也未区分总骨钙素和未羧化骨钙素。此外，大多数人体研究没有同时测量其他骨转换标志物，以将骨钙素作为骨形成的测量指标的作用与其对葡萄糖代谢的影响分开。需要精心设计的研究来确定骨钙素及其羧化或羧化不足形式在人体葡萄糖代谢调节中的作用。
Increasing evidence supports an association between the skeleton and energy metabolism. These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the evidence for a role of osteocalcin in the regulation of glucose metabolism in humans is reviewed. Osteocalcin is a bone matrix protein that regulates hydroxyapatite size and shape through its vitamin-K-dependent γ-carboxylated form. In circulation, the concentration of osteocalcin is a measure of bone formation. The undercarboxylated form of osteocalcin is reported to be active in glucose metabolism in mice. Total serum osteocalcin concentrations in humans are inversely associated with measures of glucose metabolism; however, human data are inconclusive with regard to the role of uncarboxylated osteocalcin in glucose metabolism because most studies do not account for the influence of vitamin K on the proportion of undercarboxylated osteocalcin or differentiate between the total and uncarboxylated forms of osteocalcin. Furthermore, most human studies do not concomitantly measure other bone turnover markers to isolate the role of osteocalcin as a measure of bone formation from its effect on glucose metabolism. Carefully designed studies are required to define the role of osteocalcin and its carboxylated or undercarboxylated forms in the regulation of glucose metabolism in humans.
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DOI：
10.1111/j.1440-1681.2010.05463.x
发表时间：
2011-01-01
影响因子：
2.9
作者：
Bao, Yu-Qian;Zhou, Mi;Jia, Wei-Ping
通讯作者：
Jia, Wei-Ping
影响因子：
6.2
作者：
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通讯作者：
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
7.1
作者：
Bullo, Monica;Maria Moreno-Navarrete, Jose;Salas-Salvado, Jordi
通讯作者：
Salas-Salvado, Jordi
影响因子：
15.8
作者：
Cheung AM;Tile L;Lee Y;Tomlinson G;Hawker G;Scher J;Hu H;Vieth R;Thompson L;Jamal S;Josse R
通讯作者：
Josse R