CLOSELY RELATED SEQUENCES ON HUMAN X-CHROMOSOME AND Y-CHROMOSOME OUTSIDE THE PAIRING REGION
CLOSELY RELATED SEQUENCES ON HUMAN X-CHROMOSOME AND Y-CHROMOSOME OUTSIDE THE PAIRING REGION
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DOI：
10.1038/311259a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
RAPPOLD, GA
中科院分区：
文献类型：
--
作者：
COOKE, HJ;BROWN, WAR;RAPPOLD, GA
在减数分裂期间，人类X和Y染色体形成联会复合体，其覆盖Yp的大部分和Xp的末端30%（参考文献1）。通过与常染色体的类比，这被认为反映了DNA序列的同源性。有人认为，X和Y染色体的这些区域含有相关或相同的基因座，这些基因座位于交叉位点的远端2，3，并且这些想法的支持来自于X连锁细胞表面抗原控制基因MIC 2与Y染色体上的基因相关的发现4。许多DNA序列已被证明出现在X和Y染色体上5或X，Y和常染色体上6，7。我们现在已经从Y染色体上分离出一个序列，它存在于Xq和Yq上。该区域位于配对片段之外，序列分析显示在1个双链酶对（kb）中没有碱基变化。长臂尖端附近的X和Y染色体之间的高度相似性强烈表明该区域可以发生互换。
During meiosis the human X and Y chromosomes form a synaptonemal complex which covers most of Yp and the terminal 30% of Xp (ref. 1). By analogy with the autosomes, this is presumed to reflect DNA sequence homology. It has been suggested that these regions of the X and Y chromosomes contain either related or identical loci which are distal to a site of cross-over2,3, and support for these ideas has come from the finding that an X-linked cell-surface antigen controlling geneMIC2is related to a gene on the Y chromosome4. A number of DNA sequences have been shown to occur either on the X and Y chromosomes5or on the X, Y and autosomes6,7. We have now isolated a sequence from the Y chromosome which is present on Xq and Yq. This region lies well outside the pairing segments, and sequence analysis reveals no base change in 1 kilobase pair (kb). This high degree of similarity between the X and Y chromosomes near the tips of the long arms is a strong indication that interchange can occur in this region.