Roles of NG2-glia in ischemic stroke.
Roles of NG2-glia in ischemic stroke.
复制标题
NG2-神经胶质细胞在缺血性中风中的作用。
DOI：
10.1111/cns.12690
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发表时间：
2017
影响因子：
5.5
通讯作者：
Tong XP
中科院分区：
文献类型：
--
作者：
Song FE;Huang JL;Lin SH;Wang S;Ma GF;Tong XP
最近的研究表明，一类分布广泛的神经胶质细胞，称为 NG2-神经胶质细胞，通过发育和成熟的中枢神经系统 (CNS) 中的直接突触接触与周围神经元进行快速信号传导。这种独特的神经胶质细胞群在大脑早期发育过程中具有典型的增殖和分化为少突胶质细胞的功能，这对轴突髓磷脂的形成至关重要。因此，NG2-胶质细胞也被称为少突胶质细胞前体细胞（OPC）。体外和体内研究表明，NG2-胶质细胞表达受体和离子通道对于神经元突触的快速信号传导以及生理和病理条件下神经元活动的调节具有功能意义。尽管众所周知 NG2-神经胶质细胞在多发性硬化症等脱髓鞘疾病中发挥着重要作用，但对于 NG2-神经胶质细胞或 OPCs 如何影响缺血性损伤后的神经元和脑功能却知之甚少。这篇综述总结了 NG2-神经胶质细胞在缺血性中风中的作用的最新进展，并阐述了针对大脑中的 NG2-神经胶质细胞治疗这种疾病的新方法。
Recent studies have shown that a widely distributed class of glial cells, termed NG2‐glia, engages in rapid signaling with surrounding neurons through direct synaptic contacts in the developing and mature central nervous system (CNS). This unique glial cell group has a typical function of proliferating and differentiating into oligodendrocytes during early development of the brain, which is crucial to axon myelin formation. Therefore, NG2‐glia are also called oligodendrocyte precursor cells (OPCs). In vitro and in vivo studies reveal that NG2‐glia expressing receptors and ion channels demonstrate functional significance for rapid signaling with neuronal synapses and modulation of neuronal activities in both physiological and pathological conditions. Although it is well known that NG2‐glia play an important role in demyelinating diseases such as multiple sclerosis, little is known about how NG2‐glia or OPCs impact neurons and brain function following ischemic injury. This review summarizes recent progress on the roles of NG2‐glia in ischemic stroke and illustrates new approaches for targeting NG2‐glia in the brain to treat this disease.