Probability of heterosexual transmission of HIV: Relationship to the number of unprotected sexual contacts
Probability of heterosexual transmission of HIV: Relationship to the number of unprotected sexual contacts
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DOI：
10.1097/00042560-199604010-00010
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发表时间：
1996-01-01
期刊：
影响因子：
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通讯作者：
Brunet, JB
中科院分区：
文献类型：
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作者：
Downs, AM;DeVincenzi, I;Brunet, JB
本研究的目的是调查与艾滋病毒感染者进行无保护的异性性接触的数量与艾滋病毒传播概率之间的关系。来自欧洲的一项研究涉及563名艾滋病毒感染者的异性伴侣的数据进行了分析。根据报告的无保护接触频率和可能发生传播的时间估计，可以估计525对夫妇（377对男性索引病例，148对女性索引病例）的无保护接触人数。对研究入组时的数据和随访数据（121对夫妇）进行非参数（保序回归）和参数（伯努利模型）分析。非参数分析得出了几个暴露组，感染伴侣的比例随着接触人数的增加而增加。例如，女性伴侣感染的比例从10%到10%不等，
The objective of this study was to investigate the relationship between the number of unprotected heterosexual contacts with an HIV-infected person and the probability of HIV transmission. Data from a European study involving 563 heterosexual partners of HIV-infected subjects were analyzed. The number of unprotected contacts could be estimated for 525 couples (377 with male index case, 148 with female index case) from the reported frequency of unprotected contacts and an estimate of the length of the period during which transmission could have occurred. Nonparametric (isotonic regression) and parametric (Bernoulli model) analyses were performed on data at study entry and on follow-up data (121 couples). The nonparametric analysis resulted in several exposure groups, with the proportion of infected partners increasing with the number of contacts. For example, the percentage of female partners infected ranged from 10%, among those with