Development and Evaluation of a Topical Foam Formulation for Decontamination of Warfare Agents.
Development and Evaluation of a Topical Foam Formulation for Decontamination of Warfare Agents.
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用于净化战剂的局部泡沫制剂的开发和评估。
DOI：
10.1021/acs.molpharmaceut.2c00636
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发表时间：
2022
影响因子：
4.9
通讯作者：
Banga,AjayK
中科院分区：
文献类型：
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作者：
Vora,Deepal;Dandekar,AmrutaA;Srivastava,RiteshKumar;Athar,Mohammad;Banga,AjayK
路易赛特是一种剧毒、强效的化学战发泡剂，能够引起疼痛、炎症和水泡。安全有效减轻这种损害的治疗策略非常重要。需要尽早彻底清除皮肤上的这些物质的污染，以防止其经皮吸收。在我们的研究中，我们使用砷的替代品苯胂氧化物 (PAO) 来模拟路易斯暴露。对提取溶剂的确定、皮肤提取效率、供体体积和供体浓度等各种参数进行了优化，以实现 PAO 的净化。我们的目标是开发一种新颖、易于使用的泡沫配方，可以净化砷。我们筛选了各种发泡剂、载体和化学增强剂来开发泡沫。进一步表征铅配方泡沫 F30 的泡沫密度、泡沫膨胀、泡沫液体稳定性、泡沫体积稳定性和泡沫气体分数。暴露30分钟后进入人体皮肤的PAO量为228.57±28.44μg/sq·cm。空白泡沫F30去污后残留在人体皮肤中的PAO量为50.09±9.71，总体去污效率百分比超过75%。此外，还在猪皮肤模型中测试了F30的去污效果，结果表明F30的去污效果更高。这些研究表明，所开发的泡沫配方可用于有效净化化学战剂。
Lewisite is a highly toxic and potent chemical warfare vesicating agent capable of causing pain, inflammation, and blistering. Therapeutic strategies that safely and effectively attenuate this damage are important. Early and thorough decontamination of these agents from skin is required to prevent their percutaneous absorption. In our studies, we used phenylarsine oxide (PAO), a surrogate for arsenicals, to simulate lewisite exposure. Various parameters such as determination of extraction solvents, skin extraction efficiency, donor volume, and donor concentration were optimized for decontamination of PAO. We aimed to develop a novel, easy to apply foam formulation that can decontaminate arsenicals. We screened various foaming agents, vehicles, and chemical enhancers for the development of foam. Lead formulation foam F30 was further characterized for foam density, foam expansion, foam liquid stability, foam volume stability, and foam gas fraction. The amount of PAO delivered into human skin in 30 min of exposure was 228.57 ± 28.44 μg/sq·cm. The amount of PAO remaining in human skin after decontamination with blank foam F30 was 50.09 ± 9.71, demonstrating an overall percentage decontamination efficiency of over 75%. Furthermore, the decontamination efficacy of F30 was also tested in the porcine skin model and results indicated an even higher decontamination efficacy. These studies demonstrated that the developed foam formulation can be used for effective decontamination of chemical warfare agents.