Galectin-9 in physiological and pathological conditions
Galectin-9 in physiological and pathological conditions
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DOI：
10.1023/b:glyc.0000014090.63206.2f
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Hirashima, M;Kashio, Y;Nakamura, T
我们首次克隆了Galectin-9(Galectin-9)/ecalectin作为T细胞来源的嗜酸性粒细胞趋化因子。在实验性过敏模型和人类过敏患者中，Gal-9不仅在嗜酸性粒细胞的聚集和激活中起作用，而且在体内和体外都能诱导嗜酸性粒细胞趋化，并从多个方面激活嗜酸性粒细胞。Gal-9需要二价半乳糖苷结合活性，而不是Gal-9的连接肽来发挥其生物学功能，一种未知的基质金属蛋白酶参与了Gal-9的释放。我们最近的研究还表明，Gal-9还具有其他功能，如细胞分化、聚集、黏附和死亡。现在，我们和其他研究小组正在研究Gal-9在各种生理和病理条件下的调节和功能。在这篇文章中，我们将利用我们最近的发现来展示Gal-9在生理和病理条件下的可能作用。
We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects. Gal-9 requires divalent galactoside-binding activity but not the linker peptide of Gal-9 to exhibit its biological functions, and an unidentified matrix metalloproteinase is involved in the release of Gal-9. Our recent studies also showed that Gal-9 has other functions, such as cell differentiation, aggregation, adhesion, and death. Now, we and other groups are on the way of investigating the regulation and function of Gal-9 in a variety of physiological and pathological conditions. In this article, we will show the possible role of Gal-9 in physiological and pathological conditions by using our recent findings.