First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.

First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.
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无糖尿病女性的妊娠早期血浆葡萄糖值与后代先天性心脏病的风险相关。

DOI:
10.1016/j.jpeds.2017.10.046
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发表时间:
2018-04
期刊:
The Journal of pediatrics
影响因子:
--
通讯作者:
Priest JR
Priest JR
中科院分区:
其他
文献类型:
--
作者:
Helle EIT;Biegley P;Knowles JW;Leader JB;Pendergrass S;Yang W;Reaven GR;Shaw GM;Ritchie M;Priest JR

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在一项对19171对母子的回顾性研究中,妊娠早期随机血糖值升高与后代先天性心脏病风险增加直接相关。接近心脏发育时期的血浆葡萄糖水平可能代表无糖尿病孕妇先天性心脏病的可改变危险因素。
In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
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