Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility
Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility
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DOI：
10.1038/s41598-020-60900-y
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发表时间：
2020-03-19
影响因子：
4.6
通讯作者：
Rodriguez-Palacios, Alexander
中科院分区：
文献类型：
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作者：
Basson, Abigail R.;LaSalla, Alexandria;Rodriguez-Palacios, Alexander
每年有超过70，000篇使用小鼠数据的出版物，小鼠模型代表了解决所有科学领域众多生物学问题的最佳根深蒂固的研究系统。文献中也充斥着对研究质量差和微生物组重现性的担忧。尽管众所周知，数据聚类对解释和研究能力的负面影响，但目前尚不清楚为什么科学家在实验期间经常容纳>4只小鼠/笼，而不是
With >70,000 yearly publications using mouse data, mouse models represent the best engrained research system to address numerous biological questions across all fields of science. Concerns of poor study and microbiome reproducibility also abound in the literature. Despite the well-known, negative-effects of data clustering on interpretation and study power, it is unclear why scientists often house >4 mice/cage during experiments, instead of