WOUND MANAGEMENT WITH N-CARBOXYBUTYL CHITOSAN
WOUND MANAGEMENT WITH N-CARBOXYBUTYL CHITOSAN
复制标题
DOI：
10.1016/0142-9612(91)90035-9
复制
发表时间：
1991-04-01
期刊：
影响因子：
14
通讯作者：
RIZZOLI, C
中科院分区：
文献类型：
--
作者：
BIAGINI, G;BERTANI, A;RIZZOLI, C
在接受整形手术的患者中，供皮区用冻干的N - 羧丁基壳聚糖软垫进行处理，以促进有序的组织再生。与对照供皮区相比，在真皮层观察到更好的组织结构有序性、更好的血管形成以及无炎症细胞，而在表皮层据报道马尔皮基层的增殖情况较少。因此，N - 羧丁基壳聚糖可促使皮肤组织规则排列形成，并减少异常愈合。
In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.