Highly Sensitive Wearable Sensor Based on (001)-Orientated TiO2 for Real-Time Electrochemical Detection of Dopamine, Tyrosine, and Paracetamol.
Highly Sensitive Wearable Sensor Based on (001)-Orientated TiO2 for Real-Time Electrochemical Detection of Dopamine, Tyrosine, and Paracetamol.
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DOI：
10.1002/smll.202312238
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发表时间：
2024-02
期刊：
影响因子：
13.3
通讯作者：
Tianyao Zhang;Jia Zhu;Maowen Xie;Ke Meng;Guang Yao;T. Pan;Min Gao;H. Cheng;Yuan Lin
中科院分区：
文献类型：
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作者：
Tianyao Zhang;Jia Zhu;Maowen Xie;Ke Meng;Guang Yao;T. Pan;Min Gao;H. Cheng;Yuan Lin
多巴胺（DA）和酪氨酸（Tyr）的浓度反映了帕金森病患者的病情，而适量的扑热息痛（PA）可以帮助缓解他们的疼痛。因此，这些生物分析物的实时测量对帕金森病患者具有重要的临床意义。然而，以前的传感器要么灵敏度有限，要么制造和集成过程复杂。本工作介绍了一种简单且具有成本效益的方法来制备具有高活性（001）面的高质量柔性二氧化钛（TiO 2）薄膜。所制备的由碳布电极支撑的TiO 2膜（即，TiO 2-CC）对DA（1.390 µA µM-1 cm-2）、Tyr（0.126 µA µM-1 cm-2）和PA（0.0841 µA µM-1 cm-2）具有出色的电化学特异性和灵敏度。更重要的是，在不同的pH值条件下，准确的DA浓度可以通过在一个单一的差分脉冲伏安法测量解耦，而无需额外的传感单元。TiO 2-CC电化学传感器可集成到智能尿布中以检测微量DA或集成的皮肤界面贴片，其具有微流体采样和无线传输单元，用于实时检测汗液Try和PA浓度。通过简单的制造方法制备的基于TiO 2-CC的可穿戴传感器在神经疾病患者的日常健康监测和护理中具有巨大的潜力。
The concentration of dopamine (DA) and tyrosine (Tyr) reflects the condition of patients with Parkinson's disease, whereas moderate paracetamol (PA) can help relieve their pain. Therefore, real-time measurements of these bioanalytes have important clinical implications for patients with Parkinson's disease. However, previous sensors suffer from either limited sensitivity or complex fabrication and integration processes. This work introduces a simple and cost-effective method to prepare high-quality, flexible titanium dioxide (TiO2 ) thin films with highly reactive (001)-facets. The as-fabricated TiO2 film supported by a carbon cloth electrode (i.e., TiO2 -CC) allows excellent electrochemical specificity and sensitivity to DA (1.390 µA µM-1 cm-2 ), Tyr (0.126 µA µM-1 cm-2 ), and PA (0.0841 µA µM-1 cm-2 ). More importantly, accurate DA concentration in varied pH conditions can be obtained by decoupling them within a single differential pulse voltammetry measurement without additional sensing units. The TiO2 -CC electrochemical sensor can be integrated into a smart diaper to detect the trace amount of DA or an integrated skin-interfaced patch with microfluidic sampling and wireless transmission units for real-time detection of the sweat Try and PA concentration. The wearable sensor based on TiO2 -CC prepared by facile manufacturing methods holds great potential in the daily health monitoring and care of patients with neurological disorders.