Increased circulating levels of matrix metalloproteinase-2 and-9 in women with the polycystic ovary syndrome
Increased circulating levels of matrix metalloproteinase-2 and-9 in women with the polycystic ovary syndrome
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DOI：
10.1210/jc.2005-0648
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发表时间：
2006-03-01
影响因子：
5.8
通讯作者：
Randeva, HS
中科院分区：
文献类型：
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作者：
Lewandowski, KC;Komorowski, J;Randeva, HS
基质金属蛋白酶（MMPs）与多种病理过程有关，包括炎症反应、心血管疾病，最近还与卵巢功能障碍有关。多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌疾病，其特点是慢性无排卵、胰岛素抵抗和心血管危险因素的患病率增加。MMPs及其组织抑制剂（TIMPs）的循环水平迄今尚未在多囊卵巢综合征中进行评估。材料与方法：测定23例PCOS患者血清中MMP-2、MMP-9、TIMP-1和TIMP-2的水平[年龄（平均+/- SD）， 30.5 +/- 6.7岁；体重指数，35.8 +/- 7.5 kg/m(2)]和22名健康、月经规律的女性（年龄，29.4 +/- 5.6；体重指数，31.7 +/- 9.2 kg/m(2)）。结果：PCOS女性的MMP-2（999.8 +/- 155比521.8 +/- 242 ng/ml, P < 0.001）、MMP-9（592.4 +/- 279比345 +/- 309，P = 0.007）和TIMP-1水平（823.8 +/- 145比692 +/- 210 ng/ml， P = 0.02）均显著高于对照组健康女性。PCOS女性与对照组的TIMP-2水平无差异（47.3 +/- 30 vs 44.4 +/- 39.7 ng/ml; P = 0.21）。结论：患有多囊卵巢综合征的肥胖妇女血清MMP-2和-9浓度升高。可能假设MMP浓度升高可能与PCOS患者心血管风险增加和/或与此综合征相关的月经不规则有关。
Introduction: Matrix metalloproteinases (MMPs) have been implicated in various pathological processes including inflammatory response, cardiovascular disease, and recently also in ovarian dysfunction. Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and is characterized by chronic anovulation, insulin resistance, and increased prevalence of cardiovascular risk factors. Circulating levels of MMPs and their tissue inhibitors (TIMPs) so far have not been assessed in the PCOS.Materials and Methods: Serum levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured in 23 women with PCOS [age (mean +/- SD), 30.5 +/- 6.7 yr; body mass index, 35.8 +/- 7.5 kg/m(2)] and 22 healthy, regularly menstruating women (age, 29.4 +/- 5.6; body mass index, 31.7 +/- 9.2 kg/m(2)).Results: Women with PCOS had significantly higher concentrations of MMP-2 (999.8 +/- 155 vs. 521.8 +/- 242 ng/ml; P < 0.001), MMP-9 (592.4 +/- 279 vs. 345 +/- 309; P = 0.007), and TIMP-1 levels (823.8 +/- 145 vs. 692 +/- 210 ng/ml; P = 0.02) than control healthy women. There was no difference in TIMP-2 levels (47.3 +/- 30 vs. 44.4 +/- 39.7 ng/ml; P = 0.21) between women with PCOS and controls.Conclusions: Obese women with PCOS have elevated serum concentrations of MMP-2 and -9. It might be hypothesized that elevated MMP concentrations may be related to increased cardiovascular risk in PCOS and/or menstrual irregularities associated with this syndrome.