Synthesis and antifouling activity of 3-isocyanotheonellin and its analogues
Synthesis and antifouling activity of 3-isocyanotheonellin and its analogues
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DOI：
10.1039/b206705f
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Sakaguchi, I
中科院分区：
文献类型：
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作者：
Kitano, Y;Ito, T;Sakaguchi, I
描述了 3-isocyanotheonellin 及其类似物的新合成方法，3-isocyanotheonellin 是一种海洋倍半萜，对藤壶 Balanus amphite 幼虫具有有效的防污活性。该合成策略的亮点是使用三甲基氰硅烷和银盐从醇一步构建叔异氰化物。还报道了 3-isocyanotheonellin 及其类似物的防污活性。
A new synthesis of 3-isocyanotheonellin, a marine sesquiterpene with potent antifouling activity against the larvae of the barnacle Balanus amphirite, and its analogues is described. The highlight of the synthetic strategy is the one-step construction of a tertiary isocyanide from an alcohol using trimethylsilyl cyanide and a silver salt. The antifouling activities of 3-isocyanotheonellin and its analogues are also reported.