Development of a compensation algorithm for accurate depth localization in diffuse optical tomography
Development of a compensation algorithm for accurate depth localization in diffuse optical tomography
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DOI：
10.1364/ol.35.000429
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发表时间：
2010-02-01
期刊：
影响因子：
3.6
通讯作者：
Liu, Hanli
中科院分区：
文献类型：
--
作者：
Niu, Haijing;Tian, Fenghua;Liu, Hanli
扩散光学层析成像耐受差的深度定位，因为其灵敏度随着深度的增加而严重降低。在这项研究中，我们展示了一种深度补偿算法（DCA），它最佳地平衡了光在组织中传播的衰减性质，以便准确地定位深层组织中的吸收体。DCA的新奇在于直接修改灵敏度矩阵，而不是正则化的惩罚项。DCA基于分层测量灵敏度的最大奇异值（MSV）;这些MSV被反向地用于创建平衡权重矩阵，用于补偿增加的深度中的测量灵敏度。计算机模拟和实验室实验进行了验证DCA。这些结果表明，一个（或两个）3厘米深的吸收体（S）可以准确地定位在横向平面和深度内的实验室位置误差。(C)2010年美国光学学会
Diffuse optical tomography endures poor depth localization, since its sensitivity decreases severely with increased depth. In this study, we demonstrate a depth compensation algorithm (DCA), which optimally counterbalances the decay nature of light propagation in tissue so as to accurately localize absorbers in deep tissue. The novelty of DCA is to directly modify the sensitivity matrix, rather than the penalty term of regularization. DCA is based on maximum singular values (MSVs) of layered measurement sensitivities; these MSVs are inversely utilized to create a balancing weight matrix for compensating the measurement sensitivity in increased depth. Both computer simulations and laboratory experiments were performed to validate DCA. These results demonstrate that one (or two) 3-cm-deep absorber(s) can be accurately located in both lateral plane and depth within the laboratorial position errors. (C) 2010 Optical Society of America