Prognostic factors for dogs with mammary inflammatory carcinoma: 43 cases (2003-2008)
Prognostic factors for dogs with mammary inflammatory carcinoma: 43 cases (2003-2008)
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DOI：
10.2460/javma.235.8.967
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发表时间：
2009-10-15
影响因子：
1.9
通讯作者：
Zini, Eric
中科院分区：
文献类型：
--
作者：
Marconato, Laura;Romanelli, Giorgio;Zini, Eric
描述临床特征，治疗，和结果的狗与炎性癌（IC），并确定患者，肿瘤和治疗相关因素与总生存时间。设计-回顾性病例系列。动物-43客户拥有的狗。程序-记录的狗与临床诊断的IC有组织学证据的真皮淋巴浸润进行了审查。临床分期，治疗，中毒，反应和生存时间的数据retrieved.Results-26（60%）的狗有原发性IC和17（40%）有继发性IC。初次检查时，35只（81%）犬有远处转移，2只（5%）有局部转移。29只犬中有6只（21%）出现凝血障碍。16只（37%）犬未接受针对IC的特异性治疗，24只（56%）仅接受药物治疗，2只（5%）接受手术切除并接受药物治疗，1只（2%）仅接受手术切除。41只（95%）犬的疾病进展，2只（5%）犬的疾病稳定。所有犬的平均存活时间为60天（范围：1 - 300天）。狗与凝血功能障碍的生存时间显着较短的狗没有凝血功能障碍（比值比，0.28），狗接受药物治疗的生存时间显着长于狗没有（比值比，2.54）。结论和临床相关性结果表明，乳腺IC是一种生物侵略性的条件下，狗与一个守卫的预后。此外，结果表明，药物治疗可改善结局，从而支持其在IC犬中的使用。（美国兽医医学杂志2009;235：967-972）
Objective-To describe clinical characteristics, treatment, and outcome of dogs with inflammatory carcinoma (IC) and identify patient-, tumor-, and treatment-related factors associated with overall survival time.Design-Retrospective case series.Animals-43 client-owned dogs.Procedures-Records of dogs with a clinical diagnosis of IC that had histologic evidence of dermal lymphatic invasion were reviewed. Data on clinical staging, treatment, toxicoses, response, and survival time were retrieved.Results-26 (60%) dogs had primary IC and 17 (40%) had secondary IC. Thirty-five (81%) dogs had distant metastases and 2 (5%) had local metastases at the time of initial examination. Six of 29 (21%) dogs had a coagulopathy. Sixteen (37%) dogs did not receive specific treatment for IC, 24 (56%) received medical treatment only, 2 (5%) underwent surgical excision and received medical treatment, and 1 (2%) underwent surgical excision only. Forty-one (95%) dogs had progressive disease, and 2 (5%) had stable disease. Mean survival time for all dogs was 60 days (range, I to 300 days). Dogs with a coagulopathy survived a significantly shorter time than did dogs without a coagulopathy (odds ratio, 0.28), and dogs that received medical treatment survived significantly longer than dogs that did not (odds ratio, 2.54).Conclusions and Clinical Relevance-Results suggested that mammary IC is a biologically aggressive condition in dogs associated with a guarded prognosis. In addition, results suggested that medical treatment may improve outcome, thereby supporting its use in dogs with IC. (J Am Vet Med Assoc 2009;235:967-972)