Definition of the Target Sign and its Use for the Diagnosis of schwannomas
Definition of the Target Sign and its Use for the Diagnosis of schwannomas
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DOI：
10.1097/blo.0b0136181583422
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发表时间：
2007-11-01
影响因子：
4.2
通讯作者：
Kawaguchi, Noriyoshi
中科院分区：
文献类型：
--
作者：
Koga, Hideyuki;Matsumoto, Seiichi;Kawaguchi, Noriyoshi
靶征是神经鞘瘤的特征性影像学表现之一，将其与其他软组织肿瘤区分开来，但其定义在过去的研究中有所不同。我们定义了 MRI 上的特征性靶征，并根据组织学阐明了其敏感性和特异性。在审查的 199 个神经鞘瘤中，162 个 (81%) 显示中央 Antoni A 细胞和外周 Antoni B 细胞的双相宏观和微观模式； 118 (59%) 的 MRI 也显示出双相模式。钆增强的T1加权图像显示中心高强度和外围低强度，而T2加权图像显示外围高强度和中心低强度。 78 例有囊性、出血性或坏死性变，对应于 T2 加权图像上的高强度和钆增强 T1 加权图像上的低强度。退变区域仅位于 Antoni A 中心部分的 9 例病例呈三相模式。我们将目标征象定义为 MRI 上的双相或三相模式，并且该征象与宏观和微观发现相关。神经鞘瘤目标体征的特异性为100%，敏感性为59%；因此，目标体征是神经鞘瘤的特征，有助于诊断。
The target sign is one of the characteristic imaging findings in schwannomas that distinguishes it from other soft tissue tumors, but its definition has varied in past studies. We defined the characteristic target sign on MRI and clarified its sensitivity and specificity based on histology. Of the 199 schwannomas reviewed, 162 (81%) showed biphasic macroscopic and microscopic patterns of central Antoni A and peripheral Antoni B cells; 118 (59%) also showed a biphasic pattern on MRI. Gadolinium-enhanced T1-weighted images showed central high intensity and peripheral low intensity, whereas T2-weighted images showed peripheral high intensity and central low intensity. Seventy-eight cases had cystic, hemorrhagic, or necrotic degeneration, which corresponded to high intensity on T2-weighted images and low intensity on gadolinium-enhanced T1-weighted images. Nine cases in which the degenerative area was only in the central portion of Antoni A showed a triphasic pattern. We defined the target sign as the biphasic or triphasic pattern on MRI, and the sign correlated with macroscopic and microscopic findings. The specificity of the target sign in schwannoma was 100% and the sensitivity was 59%; therefore, the target sign was characteristic of and helpful for the diagnosis of schwannomas.