Oxygen diffusion and the distribution of cellular radiosensitivity in tumours.
Oxygen diffusion and the distribution of cellular radiosensitivity in tumours.
复制标题
肿瘤中的氧扩散和细胞放射敏感性的分布。
DOI：
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发表时间：
1972
影响因子：
2.6
通讯作者：
I. Tannock
中科院分区：
文献类型：
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作者：
I. Tannock
摘要
针对氧气及其他代谢物在肿瘤血管内外的径向对称扩散问题，已对扩散方程进行了求解。针对多种不同条件，列出了预计氧分压降为零的距血管径向距离的估算值。研究表明，缺氧是导致细胞死亡和坏死的一个主要因素。推导出了氧分压、放射敏感性以及与孤立血管的径向位移之间的关系。结果显示，在肿瘤区域可能存在许多细胞，其氧分压所赋予的放射敏感性介于最小值和最大值之间。因此，仅仅假设存在最大放射敏感、氧合良好的细胞亚群以及最大抗性、缺氧的细胞亚群，无法准确地描述肿瘤。讨论了这种双室模型的局限性，并指出其使用有时可能会得出误导性结论……
Abstract The diffusion equation has been solved for radially symmetric diffusion of oxygen and other metabolites to and from tumour blood vessels. Estimates of the radial distance from a vessel at which the oxygen tension is expected to become zero are listed for a number of different conditions. It is suggested that oxygen deficiency is a major factor in the causation of cell deaths and necrosis. Relations between oxygen tension, radiosensitivity and radial displacement from an isolated blood vessel were derived. It is shown that there are likely to be many cells in regions of tumours where the oxygen tension has values conferring radiosensitivity which is intermediate between its minimum and maximum values. Thus, tumours cannot be represented accurately by only assuming subpopulations of maximally radiosensitive, well-oxygenated cells, and maximally resistant, anoxic cells. The limitations of this two-compartment model are discussed, and it is suggested that its use may sometimes give misleading conclus...