A SINGLE SOCIAL STRESS-EXPERIENCE ALTERS GLUTAMATE RECEPTOR-BINDING IN RAT HIPPOCAMPAL CA3 AREA
A SINGLE SOCIAL STRESS-EXPERIENCE ALTERS GLUTAMATE RECEPTOR-BINDING IN RAT HIPPOCAMPAL CA3 AREA
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DOI：
10.1016/0304-3940(93)90174-j
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发表时间：
1993-05-14
影响因子：
2.5
通讯作者：
KORF, J
中科院分区：
文献类型：
--
作者：
KRUGERS, HJ;KOOLHAAS, JM;KORF, J
在与主要对手对抗的社会压力后 24 小时，研究了大鼠海马体中谷氨酸受体的分布。 AMPA 型谷氨酸受体用拮抗剂 [H-3]CNQX 标记，NMDA 型受体用竞争性拮抗剂 [H-3]CGP39653 标记。 [H-3]CGP39653 标记增加仅在 CA3 放射层中发现，并且在几个海马区域发现 [H-3]CNQX 标记减少。因此，CA3 定向层和 CA3 放射层中 NMDA/AMPA 结合的比率显着增加。这些结果表明，单一的、不可避免的失败社会压力会改变兴奋性神经递质谷氨酸的影响，而这种影响仅限于海马 CA3 神经元。讨论了当前发现的可能后果。
The distribution of glutamate receptors in the rat hippocampus was investigated 24 h after the social stress of confrontation with a dominant opponent. AMPA-type glutamate receptors were labeled with the antagonist [H-3]CNQX, and NMDA-type receptors were labeled with the competitive antagonist [H-3]CGP39653. Increased [H-3]CGP39653 labeling was exclusively found in the CA3 stratum radiatum and a decreased [H-3]CNQX labeling was found in several hippocampal areas. Consequently, the ratio NMDA/AMPA binding was significantly increased in CA3 stratum oriens and CA3 stratum radiatum, These results suggest that a single unescapable social stress of defeat alters the impact of the excitatory neurotransmitter glutamate, which is restricted to hippocampal CA3 neurons. Possible consequences of the present findings are discussed.