Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles
Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles
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DOI：
10.1039/c5qo00034c
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发表时间：
2015-04
影响因子：
5.4
通讯作者：
Junwei Zhang;Xiao-Wei Liu;Q. Gu;Xiao-Xin Shi;S. You
中科院分区：
文献类型：
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作者：
Junwei Zhang;Xiao-Wei Liu;Q. Gu;Xiao-Xin Shi;S. You
建立了吡咯衍生物的烯烃交叉复分解/不对称分子内Friedel-Craft烷基化反应的序贯催化体系。用Zan-1B催化剂与手性磷酸反应合成了多种对映体富集型4，5，6，7-四氢吲哚，产率高，对映体选择性好。
A sequential catalysis involving olefin cross-metathesis/asymmetric intramolecular Friedel–Crafts alkylation of pyrrole derivatives has been developed. A variety of enantioenriched 4,5,6,7-tetrahydroindoles were obtained in good yields and enantioselectivity by combining a Zhan-1B catalyst with a chiral phosphoric acid.