Learning-dependent changes in sleep spindles and Stage 2 sleep
Learning-dependent changes in sleep spindles and Stage 2 sleep
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DOI：
10.1111/j.1365-2869.2006.00522.x
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发表时间：
2006-09-01
影响因子：
4.4
通讯作者：
Smith, Carlyle T.
中科院分区：
文献类型：
--
作者：
Fogel, Stuart M.;Smith, Carlyle T.
人们越来越清楚，睡眠对于有效巩固记忆是必要的。最近发现，第二阶段睡眠中断会损害程序性记忆表现，而记忆表现与第二阶段睡眠的持续时间相关；但睡眠期间程序记忆的突触可塑性所涉及的机制尚未确定。本研究检查了睡眠中学习依赖性的变化，包括第二阶段睡眠纺锤波。经过一段高强度的简单运动程序学习后，第二阶段睡眠的持续时间和纺锤体密度增加。任何其他睡眠阶段的持续时间或快速眼球运动的密度都没有观察到变化。这些发现支持这样的假设：睡眠纺锤波参与第二阶段睡眠期间简单运动程序记忆的离线再处理。
It has become increasingly clear that sleep is necessary for efficient memory consolidation. Recently, it has been found that Stage 2 sleep disruption impairs procedural memory performance, and that memory performance is correlated with the duration of Stage 2 sleep; but the mechanisms involved in synaptic plasticity for procedural memory during sleep have not been identified. The present study examined the learning-dependent changes in sleep, including Stage 2 sleep spindles. Following an intense period of simple motor procedural learning, the duration of Stage 2 sleep and spindle density increased. There were no changes observed in the duration of any other stage of sleep or in the density of rapid eye movements. These findings support the hypothesis that sleep spindles are involved in the off-line reprocessing of simple motor procedural memory during Stage 2 sleep.