Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy
Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy
复制标题
IgA 肾病患者血浆和尿肾上腺髓质素的测定
作者：
A. Kubo;M. Iwano;N. Minamino;H. Sato;T. Nishino;E. Hirata;Y. Akai;H. Shiiki;K. Kitamura;K. Kangawa;H. Matsuo;K. Dohi
在这项研究中，我们测定了47例伊加肾病患者的血浆和尿肾上腺髓质素（AM）浓度。对照组为39名健康志愿者。用特异性放射免疫法测定血浆和尿AM值。伊加肾病患者血浆AM浓度高于健康志愿者，尿AM浓度低于健康志愿者。血浆AM浓度与血肌酐、血尿素氮呈正相关，尿AM浓度与血肌酐、血尿素氮呈负相关。血浆AM浓度与钠和钾的排泄分数呈正相关。对无肾功能衰竭患者的肾活检标本进行活性评分（显示细胞新月体形成的肾小球百分比、系膜增生程度和间质浸润;总分= 9）。根据肾活检，与低活动性（评分0-2）组相比，高活动性（评分3-9）组的尿AM水平较低。因此，尿AM水平受伊加肾病活动程度的影响，AM可能参与伊加肾病的病理生理过程。
In this study, we measured plasma and urinary adrenomedullin (AM) concentrations in 47 patients with IgA nephropathy. Controls were 39 healthy volunteers. Plasma and urinary AM values were measured by specific radioimmunoassay. The plasma AM concentrations were higher, and the urinary AM levels were lower in patients with IgA nephropathy than in healthy volunteers. Plasma AM concentrations showed a positive correlation with serum creatinine and blood urea nitrogen, whereas urinary AM levels correlated negatively with serum creatinine and blood urea nitrogen. The plasma AM concentrations showed a positive correlation with fractional excretions of sodium and potassium. Renal biopsy specimens of patients without renal failure were scored for activity (percentage of glomeruli demonstrating cellular crescent formation, degree of mesangial proliferation and interstitial infiltration; total score = 9). Urinary AM levels were shown to be lower in the group with a high activity (score 3–9) as compared with the group with a low activity (score 0–2) based on renal biopsy. Thus, urinary levels of AM are affected by the degree of the activity in IgA nephropathy, and AM may participate in the pathophysiology of IgA nephropathy.
DOI：
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发表时间：
1995-12
期刊：
The American journal of pathology
影响因子：
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作者：
L. Iruela-Arispe;K. Gordon;C. Hugo;A. Duijvestijn;K. Claffey;M. Reilly;W. Couser;C. Alpers;Richard J. Johnson
通讯作者：
L. Iruela-Arispe;K. Gordon;C. Hugo;A. Duijvestijn;K. Claffey;M. Reilly;W. Couser;C. Alpers;Richard J. Johnson
肾上腺髓质素通过 cAMP 途径抑制大鼠系膜细胞的有丝分裂。
DOI：
10.1006/bbrc.1995.2544
发表时间：
1995
期刊：
Biochemical and biophysical research communications.
影响因子：
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作者：
Chini,EN;Choi,E;Grande,JP;Burnett,JC;Dousa,TP
通讯作者：
Dousa,TP