The feasibility of characterizing the spatial distribution of cartilage T2 using texture analysis
The feasibility of characterizing the spatial distribution of cartilage T2 using texture analysis
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DOI：
10.1016/j.joca.2007.10.019
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发表时间：
2008-05-01
影响因子：
7
通讯作者：
Majumdar, S.
中科院分区：
文献类型：
--
作者：
Blumenkrantz, G.;Stahl, R.;Majumdar, S.
目的：(1)研究绝经后骨关节炎(OA)患者和年龄匹配的健康人膝关节软骨T-2在基线状态下的空间分布特征，以及(2)分析9个月后软骨T-2的质地变化。方法：对8例轻度OA患者和10例年龄匹配的正常对照在基线和9个月后进行膝关节T-MRI检查。计算所有患者的软骨T-2、体积和平均厚度。在软骨T-2图上进行基于灰度共生矩阵的纹理分析。计算0度(对应前后轴)和90度(对应上下轴)的纹理参数，像素偏移量范围为1~3个像素。结果：最小二乘均值分析显示CA患者的平均T-2值、标准差(SD)和熵均大于对照组(P<；0.05)。9个月后，骨性关节炎患者的软骨T-2值显著降低(P<；0.05)，而软骨厚度和体积无明显变化。结论：CA患者的软骨T-2值、SD及其熵均大于正常对照组，提示骨关节炎软骨的T-2值不仅升高，而且比正常软骨更不均匀。纵向研究结果表明，在骨性关节炎的发展过程中，T-2软骨质地参数的变化可能先于厚度和体积的形态变化。(C)2007年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: The purpose of this study was (1) to characterize the spatial distribution of cartilage T-2 in postmenopausal osteoarthritis (OA) patients and age-matched healthy subjects using second order texture measures at baseline, and (2) to analyze changes in the texture of cartilage T-2 after 9 months.Methods: 3.0 T-MRI of the knee was performed in 8 mild OA patients and 10 age-matched controls at baseline and after 9 months. Cartilage T-2, volume, and average thickness were calculated in all patients. Texture analysis, based on the gray level co-occurrence matrix, was performed on the cartilage T-2 maps. Texture parameters, including entropy and angular second moment, were calculated at 0 degrees (corresponding to the anterior-posterior axis) and at 90 degrees (corresponding to the superior-inferior axis), with pixel offsets ranging from 1 to 3 pixels.Results: Least square means analysis showed that mean T-2 values, their standard deviation (SD), and their entropy were greater (P < 0.05) in CA patients than in controls. Over 9 months, the SD and entropy of cartilage T-2 significantly (P < 0.05) decreased in OA patients, while no significant changes were evident in cartilage thickness or volume.Conclusion: The mean cartilage T-2 values, their SD, and their entropy were greater in CA patients than in controls, indicating that the T-2 values in osteoarthritic cartilage are not only elevated, but also more heterogeneous than those in healthy cartilage. The longitudinal results demonstrate that changes in texture parameters of cartilage T-2 may precede morphological changes in thickness and volume in the progression of OA. (C) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.