Depressive symptoms and difficulties in emotion regulation in adult patients with epilepsy: Association with quality of life and stigma
Depressive symptoms and difficulties in emotion regulation in adult patients with epilepsy: Association with quality of life and stigma
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DOI：
10.1016/j.yebeh.2020.107073
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发表时间：
2020-06-01
影响因子：
2.6
通讯作者：
Di Lazzaro, Vincenzo
中科院分区：
文献类型：
--
作者：
Tombini, Mario;Assenza, Giovanni;Di Lazzaro, Vincenzo
目的：本研究的目的是评估成年癫痫患者（PWE）的抑郁症状（DS）和情绪调节困难（ER）及其与患者生活质量和耻辱感的相关性。材料和方法：我们连续招募了110名完成贝克抑郁量表-II（BDI-II）问卷的PWE，情绪调节困难量表（DERS）的意大利语翻译，以评估DS和ER。他们还完成了意大利版的癫痫病耻辱量表（SSE），这使得我们的患者队列和3项的Monclerby的耻辱量表（JSS）和QOLIE-31（Q31）的耻辱感和生活质量的评估耻辱感的量化。BDI-II和DERS的结果与PWE的临床细节以及Q31和SSE评分相关。结果：约30%的PWE患者出现DS，其中17.3%的PWE患者BDI-II评分> 19分，提示中重度DS。与癫痫相关的多个因素（癫痫发作频率、抗癫痫药物（AEDs）使用次数）以及ER和生活质量/污名化感知与DS显著相关。结论：PWE患者DS患病率高，且与ER困难密切相关，ER困难与生活质量和污名感知密切相关。抑郁症状和情绪失调是双向联系的，并与生活质量下降和更高的耻辱感显着相关。(C)2020爱思唯尔公司All rights reserved.
Objective: The objective of the study was to assess depressive symptoms (DS) and difficulties in emotion regulation (ER) in adult people with epilepsy (PWE) and their correlation with quality of life and stigmatization feelings of patients.Materials and methods: We enrolled consecutively 110 PWE who completed the Beck Depression Inventory-II (BDI-II) questionnaire and, for the first time, the Italian translation of Difficulties in Emotion Regulation Scale (DERS) to evaluate DS and ER. They also fulfilled the Italian version of the Stigma Scale of Epilepsy (SSE), which allowed the quantification of the stigma perception by our cohort of patients and a 3-item Jacoby's Stigma Scale (JSS) and QOLIE-31 (Q31) for the evaluation of stigma and the quality of life. The results of BDI-II and DERS were correlated with clinical details of PWE, as well as the Q31 and SSE scores. Finally, amultiple step wise regression analysis was applied to identify the main factors affecting DS and ER difficulties in these patients.Results: About 30% of PWE evidenced DS, of which 17.3% showed a BDI-II score higher than 19, suggestive of moderate to severe DS. Several factors related to epilepsy (seizure frequency, number of antiepileptic drugs (AEDs)) as well as ER and quality of life/stigmatization perception resulted significantly correlatedwith DS. As a new finding, the main factors affecting DS in PWE turned out to be the difficulties in ER and quality of life and stigma perception (as evaluated through Q31 and JSS scores).Conclusions: Our findings evidenced that DS in PWE are highly prevalent and strongly correlatedwith ER difficulties that mostly influence DS together with quality of life and stigma perception. Depressive symptoms and emotion dysregulation are linked by a bidirectional relationship and are significantly associated with worse quality of life and higher stigmatization feelings. (C) 2020 Elsevier Inc. All rights reserved.