Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure.
Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure.
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DOI：
10.21767/2471-853x.100016
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
R. Malcolm;H. Myrick;Xingbao Li;S. Henderson;K. Brady;M. George;R. See
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文献类型：
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作者：
R. Malcolm;H. Myrick;Xingbao Li;S. Henderson;K. Brady;M. George;R. See
背景技术药物相关线索呈现的神经影像学有助于理解对可卡因、酒精和尼古丁的渴望和复发的神经生物学基础。然而，对甲基苯丙胺成瘾的线索反应性成像的研究却少得多。方法 九名白人男性甲基苯丙胺依赖者和九名健康对照者在观看随机呈现的甲基苯丙胺视觉线索、中性物体和休息条件时，使用 Phillips 3.0T MRI 扫描进行扫描。使用统计参数映射软件 5 (SPM 5) 分析功能成像数据。结果 与健康对照组的冰毒图片和中性图片相比，冰毒受试者的腹侧纹状体和内侧额叶皮层有显着的大脑激活（p<0.005，阈值 15 体素）。有趣的是，腹侧纹状体的激活与上次使用冰毒后的天数显着相关（r=-0.76，p=0.017）。健康对照组未发现明显活性。结论 初步数据表明，甲基苯丙胺依赖者在暴露于与甲基苯丙胺相关的视觉线索时，腹侧纹状体、尾状核和内侧额叶皮层的大脑活动增加，从而促进渴望、药物寻求和药物使用。
BACKGROUND Neuroimaging of drug-associated cue presentations has aided in understanding the neurobiological substrates of craving and relapse for cocaine, alcohol, and nicotine. However, imaging of cue-reactivity in methamphetamine addiction has been much less studied. METHOD Nine caucasian male methamphetamine-dependent subjects and nine healthy controls were scanned in a Phillips 3.0T MRI scan when they viewed a randomized presentation of visual cues of methamphetamine, neutral objects, and rest conditions. Functional Imaging data were analyzed with Statistical Parametric Mapping software 5 (SPM 5). RESULTS Methamphetamine subjects had significant brain activation in the ventral striatum and medial frontal cortex in comparison to meth pictures and neutral pictures in healthy controls (p<0.005, threshold 15 voxels). Interestingly the ventral striatum activation significantly correlated with the days since the last use of meth (r=-0.76, p=0.017). No significant activity was found in healthy control group. CONCLUSION The preliminary data suggest that methamphetamine dependent subjects, when exposed to methamphetamine-associated visual cues, have increased brain activity in ventral striatum, caudate nucleus and medial frontal cortex which subserve craving, drug-seeking, and drug use.