Ethical framework for next-generation genome and epigenome editing.
Ethical framework for next-generation genome and epigenome editing.
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下一代基因组和表观基因组编辑的伦理框架。
DOI：
10.1080/15265161.2020.1782524
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发表时间：
2020
影响因子：
13.4
通讯作者：
Sawai T.
中科院分区：
文献类型：
--
作者：
Akatsuka K;Sasaki-Honda M;Sawai T.
Cwik（2020）通过参考现有的生殖系干预转化项目（如生殖系基因组编辑和线粒体替代疗法（MRT）），提出了一个区分生殖系干预的伦理框架，沿着四个维度（目标，目标，结果和机制）使用三个类别（转移，修订和纠正）。Cwik并不试图研究不同生殖系干预的伦理允许性，但提出了一个框架，用于确定每种干预所引起的共同和独特的技术和伦理问题。根据Cwik的说法，生殖系干预在维度方面的分解使人们能够“绘制更细粒度的允许性线”。我们同意他试图区分生殖系干预沿着维度评估伦理，法律的，和社会问题与每种类型的干预。然而，鉴于基因组和表观基因组编辑技术的快速进展，
Cwik (2020) presents an ethical framework for distinguishing germline interventions by referring to existing translational projects of germline interventions such as germline genome editing and mitochondrial replacement therapies (MRT) along four dimensions (target, goal, outcome, and mechanics) using three categories (transferring, revising, and correcting). Cwik does not attempt to examine the ethical permissibility of different germline interventions but presents a framework for identifying common and unique technical and ethical issues raised by each of the interventions. Disaggregation of germline interventions in terms of the dimensions, according to Cwik, enables one to “draw finer-grained lines of permissibility.” We concur with his attempts to distinguish germline interventions along dimensions for evaluating ethical, legal, and social issues associated with each type of intervention. However, given the rapid progress in genome and epigenome editing technologies, the