Meta-analysis of the efficacy of nicotine replacement therapy for smoking cessation: Differences between men and women
Meta-analysis of the efficacy of nicotine replacement therapy for smoking cessation: Differences between men and women
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DOI：
10.1037/0022-006x.72.4.712
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发表时间：
2004-08-01
影响因子：
5.9
通讯作者：
Erath, S
中科院分区：
文献类型：
--
作者：
Cepeda-Benito, A;Reynoso, JT;Erath, S
在对从21项双盲、安慰剂对照随机研究样本中获得的90个效应量进行荟萃分析综述时，检查了尼古丁替代疗法（NRT）疗效的性别差异。虽然NRT在3个月、6个月和12个月的随访中对男性比安慰剂更有效，但NRT对女性的益处仅在3个月和6个月的随访中明显。给予NRT结合高强度非药物支持对女性比男性更重要。也就是说，NRT和低支持仅在短期随访中对女性有效，而男性在所有随访中均受益于NRT，无论辅助支持的强度如何。结果表明，长期维持NRT治疗的收益下降更快，女性比男性。
Gender differences in the efficacy of nicotine replacement therapies (NRTs) were examined in a meta-analytical review of 90 effect sizes obtained from a sample of 21 double-blind, placebo-controlled randomized studies. Although NRT was more effective for men than placebo at 3-month, 6-month, and 12-month follow-ups, the benefits of NRT for women were clearly evident only at the 3- and 6-month follow-ups. Giving NRT in conjunction with high-intensity nonpharmacological support was more important for women than men. That is, NRT and low support were efficacious for women at only short-term follow-up, and men benefited from NRT at all the follow-ups regardless of the intensity of the adjunct support. The results suggest that long-term maintenance of NRT treatment gains decrease more rapidly for women than men.