As the fat flies: The dynamic lipid droplets of Drosophila embryos.
As the fat flies: The dynamic lipid droplets of Drosophila embryos.
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DOI：
10.1016/j.bbalip.2015.04.002
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Welte MA
中科院分区：
文献类型：
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作者：
Welte MA
对脂滴的研究正在迅速扩大，并且不断发现这些脂质储存细胞器的新细胞和有机体作用。早期果蝇胚胎特别适合解决脂滴生物学中的某些问题，并将技术优势与独特的生物现象结合起来。这篇综述总结了该实验系统的主要特征以及可用于研究它的技术，以便该领域之外的研究人员能够使用它。然后描述了该系统中研究最多的两个主题，即脂滴运动性和液滴上的蛋白质隔离，讨论了有关分子参与者的已知信息，指出了悬而未决的问题，并将果蝇胚胎研究的结果与其他系统中脂滴的已知信息进行了比较。
Research into lipid droplets is rapidly expanding, and new cellular and organismal roles for these lipid storage organelles are continually being discovered. The early Drosophila embryo is particularly well suited for addressing certain questions in lipid-droplet biology and combines technical advantages with unique biological phenomena. This review summarizes key features of this experimental system and the techniques available to study it, in order to make it accessible to researchers outside this field. It then describes the two topics most heavily studied in this system, lipid-droplet motility and protein sequestration on droplets, discusses what is known about the molecular players involved, points to open questions, and compares the results from Drosophila embryo studies to what it is known about lipid droplets in other systems.