Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis
Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis
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DOI：
10.1007/s002960050069
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发表时间：
1998-10-01
影响因子：
4
通讯作者：
Valdimarsson, H
中科院分区：
文献类型：
--
作者：
Jonsson, T;Steinsson, K;Valdimarsson, H
比较了凝集法和同种型特异性酶联免疫吸附试验（ELISA）检测类风湿因子（RF）的诊断价值。该研究包括70例类风湿性关节炎（RA）患者和205例各种其他风湿性疾病患者。在RA患者中，74%的RF阳性凝集和90%的一个或多个RF同种型升高ELISA相比，14%和22%，分别为其他患者。值得注意的是，70%的RF阳性RA患者有两种或两种以上的RF同种型升高，而其他RE阳性患者只有16%（P
The diagnostic value of measuring rheumatoid factor (RF) by agglutination or isotype-specific enzyme-linked immunosorbent assay (ELISA) was compared. The study included 70 patients with rheumatoid arthritis (RA) and 205 patients with various other rheumatic conditions. Of the RA patients, 74% were RF-positive by agglutination and 90% had one or more RF isotypes elevated by ELISA compared to 14% and 22%, respectively, of the other patients. Strikingly, 70% of the RF-positive RA patients had an elevation of two or more RF isotypes compared to only 16% of the other RE-positive patients (P