A Widely Applicable AIE Chemosensor for On-site Fast Detection of Drugs Based on POSS-core Dendrimer with Controlled Self-assembly Mechanism
A Widely Applicable AIE Chemosensor for On-site Fast Detection of Drugs Based on POSS-core Dendrimer with Controlled Self-assembly Mechanism
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基于具有受控自组装机制的 POSS 核心树枝状聚合物的一种广泛适用的 AIE 化学传感器，用于现场快速检测药物
DOI：
10.1021/acs.langmuir.8b03275
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发表时间：
2019
期刊：
影响因子：
3.9
通讯作者：
Xu Wang
中科院分区：
文献类型：
--
作者：
Zhihang An;Si Chen;Xiaoqian Tong;Huiwen He;Jin Han;Meng Ma;Yanqin Shi;Xu Wang
首次报道了一种新型的荧光化学传感器，该传感器能够快速地对合成药物进行现场检测和预筛选。设计并合成了一种八苯乙烯（TPE）修饰的多面体低聚倍半硅氧烷（POSS）树枝状分子作为聚集诱导发射（AIE）化学传感器，由于形成了不同的自组装形态，该树枝状分子在纯四氢呋喃（THF）中表现出独特的单体发射和在THF/水中的AIE发射显著增强。此外，即使在人工唾液中，POSS-TPE也可以通过非共价相互作用力灵敏地检测甲基苯丙胺和氯胺酮。该传感器有望成为一种新型的芳香族分子的AIE化学传感器。
A novel fluorescence chemosensor that can quickly on-site detect synthetic drugs and undergo prescreening is first reported. An eight tetraphenylethene (TPE)-modified polyhedral oligomeric silsesquioxane (POSS) dendrimer is designed and synthesized as an aggregation-induced emission (AIE) chemosensor, which exhibits great enhancement of unique monomer emission in pure tetrahydrofuran (THF) and AIE emission in THF/water, thanks to forming different self-assembly morphologies. In addition, POSS-TPE can sensitively detect methamphetamine and ketamine even in artificial saliva by noncovalent interaction forces. It has great potential to be a new widely applicable AIE chemosensor for aromatic molecules.