Failing to deactivate: Resting functional abnormalities in autism
Failing to deactivate: Resting functional abnormalities in autism
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DOI：
10.1073/pnas.0600674103
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发表时间：
2006-05-23
影响因子：
11.1
通讯作者：
Courchesne, E
中科院分区：
文献类型：
--
作者：
Kennedy, DP;Redcay, E;Courchesne, E
大脑的几个区域（包括内侧前额叶皮层、扣带前吻侧、扣带后吻侧和楔前叶）在休息时具有高代谢活动，在认知要求高的任务中被抑制。通过功能性磁共振成像（fMRI），这种活动的抑制被观察为“失活”，这被认为是在休息期间持续的精神活动中断的指示。因此，测量失活提供了一种可以定量检查休息相关功能活动的方法。将这种方法应用于自闭症，我们发现自闭症组未能证明这种失活效应。此外，社交障碍的临床测量与腹侧内侧前额叶皮层的功能活动之间存在很强的相关性。我们推测，自闭症组中缺乏失活表明休息时内部定向过程异常，这可能是自闭症社交和情感缺陷的重要原因。
Several regions of the brain (including medial prefrontal cortex, rostral anterior cingulate, posterior cingulate, and precuneus) are known to have high metabolic activity during rest, which is suppressed during cognitively demanding tasks. With functional magnetic resonance imaging (fMRI), this suppression of activity is observed as "deactivations," which are thought to be indicative of an interruption of the mental activity that persists during rest. Thus, measuring deactivation provides a means by which rest-associated functional activity can be quantitatively examined. Applying this approach to autism, we found that the autism group failed to demonstrate this deactivation effect. Furthermore, there was a strong correlation between a clinical measure of social impairment and functional activity within the ventral medial prefrontal cortex. We speculate that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism.