Leading Neuroblastoma Cells To Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct
Leading Neuroblastoma Cells To Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct
复制标题
多功能纳米结构的多次预谋攻击导致神经母细胞瘤细胞死亡
DOI：
10.1021/ja206118a
复制
发表时间：
2011-09-07
影响因子：
15
通讯作者：
Yan, Bing
中科院分区：
文献类型：
--
作者：
Jiao, Peifu;Zhou, Hongyu;Yan, Bing
为了战胜癌症等复杂和毁灭性的疾病，需要更协调和联合的攻击战略。我们认为，这些可以通过使用纳米结构设计漂亮地实现。我们提出了一个例子，表明神经母细胞瘤细胞被一种纳米结构选择性地杀死，这种纳米结构特异性地靶向神经母细胞瘤细胞，将细胞推向细胞周期的脆弱阶段，并大大增强辐射诱导的细胞死亡。这种由细胞包埋纳米结构发起的多管齐下的攻击方法的成功证明了纳米技术在治疗癌症方面的力量和灵活性，这对小分子来说是一项艰巨的任务。
To conquer complex and devastating diseases such as cancer, more coordinated and combined attack strategies are needed. We suggest that these can be beautifully achieved by using nanoconstruct design. We present an example showing that neuroblastoma cells are selectively killed by a nanoconstruct that specifically targets neuroblastoma cells, pushes cells to the vulnerable phase of the cell cycle, and greatly enhances radiation-induced cell death. The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule.