18F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancer
18F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancer
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DOI：
10.3748/wjg.v17.i2.231
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发表时间：
2011-01-14
影响因子：
4.3
通讯作者：
Suzuki, Yasuyuki
中科院分区：
文献类型：
--
作者：
Okano, Keiichi;Kakinoki, Keitaro;Suzuki, Yasuyuki
目的：探讨18F-脱氧葡萄糖正电子发射断层扫描(FDG-PET)在小胰腺癌诊断中的价值。根据肿瘤最大径分为3组：Ts1组(肿瘤最大径2.0 cm、4.0 cm)。结果：肿瘤直径1.3~11.0 cm。31例患者中有30例(97%)FDG-PET检查呈阳性。TS1型5例，TS2型15例，TS3-4型11例。FDG-PET、CT、MRI对TS1的敏感性分别为100%、40%、0%，对TS2的敏感性为93%、93%、89%，对TS3-4的敏感性为100%、100%、100%。在TS1患者中，FDGPET的敏感性显著高于CT和MRI(P<；0.032)。平均标准摄取值(SUV)与TS无显著差异(TS1：5.8+/-4.5，TS2：5.7+/-2.2，TS3-4：8.2+/-3.9)。所有TS1肿瘤(13~20 mm)在延迟期FDG-PET的双时相点SUV均高于早期，提示肿瘤为恶性肿瘤。结论：双时点FDG-PET是诊断直径小于20 mm的小胰腺癌的一种有效方法。(C)2011年白石登。版权所有。
AIM: To investigate the role of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the diagnosis of small pancreatic cancer.METHODS: This study involved 31 patients with proven invasive ductal cancer of the pancreas. The patients were divided into 3 groups according to the maximum diameter of the tumor: TS1 (maximum tumor size 2.0 cm and 4.0 cm). The relationships between the TS and various diagnostic tools, including FDG-PET with dual time point evaluation, were analyzed.RESULTS: The tumors ranged from 1.3 to 11.0 cm in diameter. Thirty of the 31 patients (97%) had a positive FDG-PET study. There were 5 patients classified as TS1, 15 as TS2 and 11 as TS3-4. The sensitivity of FDG-PET, computed tomography (CT) and magnetic resonance imaging (MRI) were 100%, 40%, 0% in TS1, 93%, 93%, 89% in TS2 and 100%, 100%, 100% in TS3-4. The sensitivity of FDG-PET was significantly higher in comparison to CT and MRI in patients with TS1 (P < 0.032). The mean standardized uptake values (SUVs) did not show a significant difference in relation to the TS (TS1: 5.8 +/- 4.5, TS2: 5.7 +/- 2.2, TS3-4: 8.2 +/- 3.9), respectively. All the TS1 tumors (from 13 to 20 mm) showed higher SUVs in FDG-PET with dual time point evaluation in the delayed phase compared with the early phase, which suggested the lesions were malignant.CONCLUSION: These results indicate that FDG-PET with dual time point evaluation is a useful modality for the detection of small pancreatic cancers with a diameter of less than 20 mm. (C) 2011 Baishideng. All rights reserved.