THE BRITISH-ISLES SURVEY OF MULTIPLE-SCLEROSIS IN TWINS
THE BRITISH-ISLES SURVEY OF MULTIPLE-SCLEROSIS IN TWINS
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DOI：
10.1212/wnl.44.1.11
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发表时间：
1994-01-01
期刊：
影响因子：
9.9
通讯作者：
COMPSTON, DAS
中科院分区：
文献类型：
--
作者：
MUMFORD, CJ;WOOD, NW;COMPSTON, DAS
在27个月的招募期间，我们确定了146名患有多发性硬化症（MS）的双胞胎。一位临床医生采访并检查了105对双胞胎，我们用小卫星探针确认了卵性。包括两个疑似病例，44对同卵双胞胎中有11对（25%）与61对异卵双胞胎中的2对（3%）一致，其中33对（6%）为同性双胞胎中的2对，28对（0%）为异性双胞胎中的0对。在105对双胞胎中的64对中进行了MRI，并且在13%的单卵双胞胎和9%的双卵双胞胎中显示出与脱髓鞘一致的异常，这些双胞胎临床上未受影响。这些结果与大多数先前在双胞胎中进行的MS研究结果相似，其中卵性未明确确定，并且大多数临床上未受影响的双胞胎未通过MRI进行研究;单卵和双卵双胞胎一致率的差异表明MS病因中存在显著的遗传成分。
During a 27-month recruitment period, we identified 146 individuals with multiple sclerosis (MS) who have a twin. A single clinician interviewed and examined 105 pairs of twins, and we confirmed zygosity using minisatellite probes. Including two suspected cases, 11 of 44 (25%) monozygotic twin pairs were concordant compared with two of 61 (3%) dizygotic twin pairs-two of 33 (6%) like-sexed and zero of 28 (0%) opposite-sexed. MRI was performed in 64 of 105 co-twins, and showed abnormalities consistent with demyelination in 13% of monozygotic and 9% of dizygotic co-twins who were clinically unaffected. These findings are similar to the results of most previous studies of MS in twins in which zygosity was not unequivocally established and where the majority of clinically unaffected co-twins were not studied by MRI; the difference in concordance rates in monozygotic and dizygotic twins indicates a significant genetic component in the etiology of MS.