Association between transillumination breast spectroscopy and quantitative mammographic features of the breast
Association between transillumination breast spectroscopy and quantitative mammographic features of the breast
复制标题
DOI：
10.1158/1055-9965.epi-07-2658
复制
发表时间：
2008-05-01
影响因子：
3.8
通讯作者：
Lilge, Lothar
中科院分区：
文献类型：
--
作者：
Blackmore, Kristina M.;Knight, Julia A.;Lilge, Lothar
透照乳房光谱学（TiBS）使用非电离光辐射直接从乳房获得有关组织特性的信息。对225名乳房x光检查正常的妇女进行TiBS测量。使用主成分分析将光谱数据集简化为四个主成分，并为每位女性生成四个TiBS分数(t（1)-t(4)）。这些成分和分数代表光散射、水、脂质和血红蛋白的含量。用积云测量密度百分比、密集面积和非密集面积。TiBS评分与定量乳房x线摄影特征之间的关系采用绝经状态分层的线性回归分析，并根据体重指数进行调整。在绝经前妇女中，t(1)和t(3)与百分比密度显著相关(β (t1) = -0.14, P = 0.04；β (t3) = -2.43, P < 0.0001)，而t(2)和t(3)与密集面积显著相关(β (t2) = -1.57, P < 0.0001；β (t3) = -2.54, P < 0.0001)。在绝经后妇女中，t(1)、t3和t(4)与百分比密度显著相关（β t(1) = -0.30, P < 0.0001;）
Transillumination breast spectroscopy (TiBS) uses nonionizing optical radiation to gain information about tissue properties directly from the breast. TiBS measurements were obtained from 225 women with normal mammograms. Principal component analysis was used to reduce the spectral data set into four principal components and to generate four TiBS scores (t(1)-t(4) for each woman. These components and scores represent light scattering, water, lipid, and hemoglobin content. Percent density, dense area, and nondense area were measured using Cumulus. The association between TiBS scores and quantitative mammographic features was analyzed using linear regression stratified by menopausal status and adjusted for body mass index. Among premenopausal women, t(1) and t(3) were significantly associated with percent density (beta(t1) = -0.14, P = 0.04; beta(t3) = -2.43, P < 0.0001), whereas t(2) and t(3) were significantly associated with dense area (beta(t2) = -1.57, P < 0.0001; beta(t3) = -2.54, P < 0.0001). Among postmenopausal women, t(1), t3, and t(4) were significantly associated with percent density (beta t(1) = -0.30, P < 0.0001;)