Microwave promoted C6-alkylation of purines through SNAr-based reaction of 6-chloropurines with 3-alkyl-acetylacetone
Microwave promoted C6-alkylation of purines through SNAr-based reaction of 6-chloropurines with 3-alkyl-acetylacetone
复制标题
微波通过 6-氯嘌呤与 3-烷基乙酰丙酮的 SNAr 反应促进嘌呤的 C6-烷基化
DOI：
10.1039/c0ob01213k
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Qu, Gui-Rong
中科院分区：
文献类型：
--
作者：
Guo, Hai-Ming;Zhang, Yu;Qu, Gui-Rong
6-氯嘌呤衍生物与3-烷基乙酰丙酮进行SNAr反应，得到了c6 -烷基嘌呤类似物，分离收率较高。以3-烷基乙基丙酮为烷基化剂，在微波辐照条件下，在短时间内选择性地得到了c6 -烷基化嘌呤。本研究是对经典偶联反应合成c6 -烷基化嘌呤类似物的补充。
C6-Alkylated purine analogues were obtained in good to excellent isolated yields by SNAr reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone. 3-Alkylacetylacetones were employed as alkylating agents and C6-alkylated purines were obtained highly selectively within short reaction time under microwave irradiation conditions. This work is complementary to the classical coupling reactions for the synthesis of C6-alkylated purine analogues.