Conical scan polarization-sensitive optical coherence tomography.
Conical scan polarization-sensitive optical coherence tomography.
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DOI：
10.1364/boe.5.000752
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发表时间：
2014-03
影响因子：
3.4
通讯作者：
Zenghai Lu;Deepa Kasaragod;S. Matcher
中科院分区：
文献类型：
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作者：
Zenghai Lu;Deepa Kasaragod;S. Matcher
我们报告了一种新的关节软骨成像技术，具有临床关节镜使用的潜力，通过补充可变入射角偏振敏感光学相干断层扫描方法，我们以前开发的锥形光束扫描协议。通过比较实验数据与使用扩展的琼斯矩阵演算生成的模拟数据，牛肌腱上的技术进行了验证。这种新的光学技术的独特能力是，它可以定位关节软骨中胶原纤维的“刷方向”，这是结构信息，其延伸超出了诸如分裂线摄影或双折射快轴测量的已建立的方法，因为它在（-π，+ π）的整个方位角范围内被唯一地定义。这个方向在软骨表面上的映射可以为软骨修复的组织工程支架的最佳设计提供见解。
We report on a new articular cartilage imaging technique with potential for clinical arthroscopic use, by supplementing the variable-incidence-angle polarization-sensitive optical coherence tomography method previously developed by us with a conical beam scan protocol. The technique is validated on bovine tendon by comparing experimental data with simulated data generated using the extended Jones matrix calculus. A unique capability of this new optical technique is that it can locate the "brushing direction" of collagen fibers in articular cartilage, which is structural information that extends beyond established methods such as split-line photography or birefringent fast-axis measurement in that it is uniquely defined over the full azimuthal-angle range of (-π, + π). The mapping of this direction over the cartilage surface may offer insights into the optimal design of tissue-engineering scaffolds for cartilage repair.