In vivo analysis of physiological 3D blood flow of cerebral veins
In vivo analysis of physiological 3D blood flow of cerebral veins
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DOI：
10.1007/s00330-014-3587-x
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发表时间：
2015-08-01
影响因子：
5.9
通讯作者：
Harloff, Andreas
中科院分区：
文献类型：
--
作者：
Schuchardt, Florian;Schroeder, Laure;Harloff, Andreas
为了使用时间分辨的3D相位对比MRI（4D flow MRI）可视化和量化颅内静脉的生理血流，并测试测量准确性，15名健康志愿者重复进行ECG触发的4D flow MRI（3T，32通道头部线圈）。使用专用软件分析颅内静脉血流量，允许在上级矢状窦、直窦和横窦的分析平面中进行血流可视化和定量。评价MRI的观察者内和观察者间一致性和扫描重扫描再现性。将横窦的测量结果与经颅二维多普勒超声进行比较，在100%的志愿者中，脑窦内的3D血流可视化是可行的，在87%的志愿者中，至少有一条脑深静脉。血流速度/容量沿上级矢状窦沿着增加，左侧低于右侧横窦。血流速度（平均差异0.01/0.02/0.02 m/s）和血流量（平均差异0.0002/-0.0003/0.00003 l/s）的观察者内和观察者间可靠性和再现性为良好至极好。高/低速度更明显（8%高估/9%低估）。四维流动MRI可靠地可视化和量化三维成像，Euro cent 4D flow MRI可用于可视化和定量生理脑静脉血流动力学Euro cent脑静脉内血流定量窦显示4D血流MRI的高可靠性和准确性沿上矢状窦的血流量和速度增加有限的空间分辨率目前妨碍了小脑静脉中的血流定量。
To visualize and quantify physiological blood flow of intracranial veins in vivo using time-resolved, 3D phase-contrast MRI (4D flow MRI), and to test measurement accuracy.Fifteen healthy volunteers underwent repeated ECG-triggered 4D flow MRI (3 Tesla, 32-channel head coil). Intracranial venous blood flow was analysed using dedicated software allowing for blood flow visualization and quantification in analysis planes at the superior sagittal, straight, and transverse sinuses. MRI was evaluated for intra- and inter-observer agreement and scan-rescan reproducibility. Measurements of the transverse sinuses were compared with transcranial two-dimensional duplex ultrasound.Visualization of 3D blood flow within cerebral sinuses was feasible in 100 % and within at least one deep cerebral vein in 87 % of the volunteers. Blood flow velocity/volume increased along the superior sagittal sinus and was lower in the left compared to the right transverse sinus. Intra- and inter-observer reliability and reproducibility of blood flow velocity (mean difference 0.01/0.02/0.02 m/s) and volume (mean difference 0.0002/-0.0003/0.00003 l/s) were good to excellent. High/low velocities were more pronounced (8 % overestimation/9 % underestimation) in MRI compared to ultrasound.Four-dimensional flow MRI reliably visualizes and quantifies three-dimensional cerebral venous blood flow in vivo and is promising for studies in patients with sinus thrombosis and related diseases.aEuro cent 4D flow MRI can be used to visualize and quantify physiological cerebral venous haemodynamicsaEuro cent Flow quantification within cerebral sinuses reveals high reliability and accuracy of 4D flow MRIaEuro cent Blood flow volume and velocity increase along the superior sagittal sinusaEuro cent Limited spatial resolution currently precludes flow quantification in small cerebral veins.