Thalamocortical circuitry and alpha rhythm slowing: An empirical study based on a classic computational model
Thalamocortical circuitry and alpha rhythm slowing: An empirical study based on a classic computational model
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丘脑皮质回路和α节律减慢：基于经典计算模型的实证研究
DOI：
10.1109/ijcnn.2010.5596647
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
L. Maguire
中科院分区：
文献类型：
--
作者：
B. Bhattacharya;D. Coyle;L. Maguire
本文描述了一个研究的影响，在丘脑皮层突触活动的变化对α节律（8 - 13赫兹）使用的计算模型。该研究旨在研究与阿尔茨海默病相关的α节律减慢。观察到，对于输入值的一定范围，抑制活性的增加导致较低α频带（8 - 10 Hz）功率的增加和较高α频带（11 - 13 Hz）功率的相应减少，从而指示α节律的减慢。另一方面，兴奋性突触活动的增加导致输出信号中的峰值功率从较低的α频带到较高的α频带的整体移位。然而，对于该范围之外的输入值，输出信号表现出行为上的分叉并进入极限环模式。在这种状态下，输出功率主要位于较低的阿尔法带。抑制性或兴奋性突触参数的变化对输出功率的频带影响很小或没有影响。
This paper describes a study of the effects of variations in the thalamocortical synaptic activity on alpha rhythms (8 – 13 Hz) using a computational model. The study aims to investigate alpha rhythm slowing associated with Alzheimer's Disease. It is observed that for a certain range of values of the input, an increase in inhibitory activity results in an increase of the lower alpha band (8 – 10 Hz) power and a corresponding decrease in the upper alpha band (11 – 13 Hz) power, thus indicating a slowing of the alpha rhythms. On the other hand, an increase in the excitatory synaptic activity results in an overall shift of the peak power in the output signal from the lower alpha band to the upper alpha band. However, for values of input outside this range, the output signal shows a bifurcation in behaviour and enters a limit cycle mode. In this state, the output power lies dominantly in the lower alpha band. Variation in the inhibitory or excitatory synaptic parameters has little or no effect on the frequency band of the output power.