Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering.
Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering.
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DOI：
10.1007/s40883-016-0022-7
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发表时间：
2017-03
影响因子：
2.6
通讯作者：
Laurencin CT
中科院分区：
文献类型：
--
作者：
Ogueri KS;Escobar Ivirico JL;Nair LS;Allcock HR;Laurencin CT
肌肉骨骼组织损伤或疾病的发生以及随后的功能损害以惊人的速度发生。它仍然是人类卫生保健中最具挑战性的问题之一。基于组织工程、先进材料科学、干细胞科学、发育生物学和临床翻译的融合，再生工程为组织再生提供了一种很有前途的跨学科策略。生物材料正在作为细胞外模拟基质出现，旨在提供控制细胞行为的指导性线索，并最终被应用于再生受损组织的治疗。生物可降解聚合物因其在化学上的灵活性和可被人体排泄或吸收的能力而成为开发支架材料的一类有吸引力的生物材料。在这里，重点将放在可生物降解的聚磷腈共混体系上。聚磷腈的合成灵活性与独特的无机骨架相结合，为更多的研究和随后开发能够与聚丙交酯-乙交酯(Plaga)形成可混溶共混的新型材料提供了跳板。Laurencin及其同事展示了对聚磷腈合成灵活性的开发，这将使设计新型聚合物成为可能，这种聚合物可以与Plaga形成可混溶的混合物，用于生物医学应用。这些新型混合物由于其良好的生物降解性、力学和生物特性以及降解产物的缓冲能力，是各种肌肉骨骼组织再生的理想材料。再生工程的目标是再生复杂的组织，以应对器官损伤的临床挑战。组织工程学主要关注单个组织和器官的修复和修复，但在过去的25年里，科学、工程和医学的进步导致了这种新方法的引入，其中包括复杂组织和生物系统的再生，如膝盖或整个肢体。虽然已经开发了许多优秀的先进生物材料，但在过去几年中，生物材料的选择有所增加，包括可以设计成具有一系列机械性能、降解率和化学功能的聚合物。聚磷腈就是一个很好的例子。它们的化学多功能性和氢键能力鼓励与其他生物相关聚合物混合。聚磷腈共混物的进一步发展将提供更广泛的先进生物材料，可用作再生工程和其他生物医学应用的支架。
The occurrence of musculoskeletal tissue injury or disease and the subsequent functional impairment is at an alarming rate. It continues to be one of the most challenging problems in the human health care. Regenerative engineering offers a promising transdisciplinary strategy for tissues regeneration based on the convergence of tissue engineering, advanced materials science, stem cell science, developmental biology and clinical translation. Biomaterials are emerging as extracellular-mimicking matrices designed to provide instructive cues to control cell behavior and ultimately, be applied as therapies to regenerate damaged tissues. Biodegradable polymers constitute an attractive class of biomaterials for the development of scaffolds due to their flexibility in chemistry and the ability to be excreted or resorbed by the body. Herein, the focus will be on biodegradable polyphosphazene-based blend systems. The synthetic flexibility of polyphosphazene, combined with the unique inorganic backbone, has provided a springboard for more research and subsequent development of numerous novel materials that are capable of forming miscible blends with poly (lactide-co-glycolide) (PLAGA). Laurencin and co-workers has demonstrated the exploitation of the synthetic flexibility of Polyphosphazene that will allow the design of novel polymers, which can form miscible blends with PLAGA for biomedical applications. These novel blends, due to their well-tuned biodegradability, and mechanical and biological properties coupled with the buffering capacity of the degradation products, constitute ideal materials for regeneration of various musculoskeletal tissues. Regenerative engineering aims to regenerate complex tissues to address the clinical challenge of organ damage. Tissue engineering has largely focused on the restoration and repair of individual tissues and organs, but over the past 25 years, scientific, engineering, and medical advances have led to the introduction of this new approach which involves the regeneration of complex tissues and biological systems such as a knee or a whole limb. While a number of excellent advanced biomaterials have been developed, the choice of biomaterials, however, has increased over the past years to include polymers that can be designed with a range of mechanical properties, degradation rates, and chemical functionality. The polyphosphazenes are one good example. Their chemical versatility and hydrogen bonding capability encourages blending with other biologically relevant polymers. The further development of Polyphosphazene-based blends will present a wide spectrum of advanced biomaterials that can be used as scaffolds for regenerative engineering and as well as other biomedical applications.