Metamorphosis-dependent recognition of larval skin as non-self by inbred adult frogs (Xenopus laevis).
Metamorphosis-dependent recognition of larval skin as non-self by inbred adult frogs (Xenopus laevis).
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近交成蛙（非洲爪蟾）对幼虫皮肤的变态依赖性识别为非自身。
DOI：
10.1002/jez.1402660211
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
K. Yoshizato
中科院分区：
文献类型：
--
作者：
Y. Izutsu;K. Yoshizato
无尾蝌蚪组织中的幼虫细胞在变形过程中被相应组织中的成体细胞所取代。作为这种替换的一个极端例子，尾巴的组织，在成人中没有对应的，在变态过程中完全消失了。我们推测某些免疫识别机制可能参与了这种特异性尾部组织的消除。通过将皮肤移植技术应用于近交系非洲爪蟾J株接受同种异体移植的个体，验证了我们的工作假设。我们证明了年轻的成年人排斥来自幼虫的皮肤移植。这种排斥在本质上是免疫的，因为观察到排斥的二次反应。尾巴和身体的移植排斥反应明显不同。不论供体的变态阶段如何，尾皮移植均被排斥。相比之下，随着供体的蜕变，人体皮肤移植变得可以接受。幼虫皮肤的平均存活时间比其他研究者报道的主要组织相容性复合体(MHC)-不同皮肤移植物的平均存活时间要长得多，这表明本研究中描述的排斥反应是由于次要组织相容性（minor- h）抗原的差异。我们提出免疫识别机制参与特异性检测和消除幼虫细胞在尾巴的过程。
Larval cells in tissues of the anuran tadpole are replaced by adult cells in the corresponding tissue of the frog during metamorphosis. As an extreme example of such replacement, tissues of the tail, which have no counterpart in the adult, are completely eliminated during metamorphosis. We postulated that some immunological recognition mechanism might be involved in this specific elimination of the tail tissue. Our working hypothesis was tested by applying the skin transplantation technique to individuals of the inbred J strain of Xenopus laevis, which accept homografts. We demonstrated that young adults reject skin grafts from larvae. This rejection was immunological in nature because the secondary response of rejection was observed. There was a clear difference in graft rejection between grafts from the tail and those from the body. Grafts of tail skin were rejected irrespective of the metamorphic stages of donors. By contrast, grafts of body skin became acceptable as donors metamorphosed. The mean survival time of the larval skin was much longer than that of major histocompatibility complex (MHC)-disparate skin grafts reported by other investigators, suggesting that the rejection described in the present study is due to disparity in minor histocompatible (minor-H) antigens. We propose the involvement of the immunological recognition mechanism in the process of specific detection and elimination of larval cells in the tail.
影响因子：
6.4
作者：
DiMarzo,SJ;Cohen,N
通讯作者：
Cohen,N
甲状腺素驱动的性早熟对早期甲状腺切除青蛙成年型同种异体移植排斥反应成熟的影响。
DOI：
10.1111/j.1432-0436.1988.tb00719.x
发表时间：
1988
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Rollins-Smith,LA;Parsons,SC;Cohen,N
通讯作者：
Cohen,N