Congenital and perinatal cytomegalovirus infections.
Congenital and perinatal cytomegalovirus infections.
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DOI：
10.1093/clinids/12.supplement_7.s745
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发表时间：
1990-09
期刊：
影响因子：
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通讯作者：
C. Alford;S. Stagno;R. F. Pass;W. Britt
中科院分区：
文献类型：
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作者：
C. Alford;S. Stagno;R. F. Pass;W. Britt
巨细胞病毒是全世界先天性和围产期病毒感染的最常见原因。在发达国家，先天性感染发生在所有活产婴儿中的1%，在发展中国家，这一比例更高。由于在分娩期间、通过母乳和通过输血传播，围产期感染比先天性感染更为普遍。这些感染绝大多数是慢性、亚临床形式，但有症状的感染足够普遍和危险，足以代表世界各地一个尚未解决的重大公共卫生问题。在这篇综述中，将讨论孕妇及其后代巨细胞病毒感染的流行病学、临床、免疫学和治疗方面。
Cytomegalovirus is the most common cause of congenital and perinatal viral infections throughout the world. Congenital infection occurs in 1% of all live births in developed countries and in an even higher percentage in developing nations. As a result of transmission during birth, by breast milk, and by blood transfusion, perinatal infections are much more prevalent than congenital infections. The vast majority of these infections are chronic, subclinical forms, but symptomatic infections are sufficiently prevalent and dangerous to represent a major unsolved public health problem throughout the world. In this review the epidemiologic, clinical, immunologic, and therapeutic facets of cytomegaloviral infections in pregnant women and their offspring will be discussed.